Strain Data Sheet

RBRC00052

Strain Information

Image
BRC No.RBRC00052
TypeWild-derived Inbred and Spontaneous Mutation
SpeciesMus musculus molossinus
Strain nameSHL
Former Common namehyperlipidemia
H-2 Haplotype
ES Cell line
Background strainKOR [Mus musculus molossinus]
Appearancewhite belly agouti
Strain developmentSpontaneous mutation arose in KOR wild-derived mouse colony. The mutant mice were maintained by sibling mating.
Strain descriptionSHL, spontaneously hyperlipidemia mutant mice. Spontaneous mutation arose in KOR mouse colony derived from Japanese wild-mice (Mus musculus molossius). Homozygous mutant mice show increased circulating cholesterol level. Homozygous mutant mice are viable and fertile (before onset of xanthoma). Females of homozygote show lower reproductive performance.
Colony maintenance
References
Spontaneously hyperlipidemic (SHL) mice: Japanese wild mice with apolipoprotein E deficiency.
Matsushima Y, Hayashi S, Tachibana M
Mamm. Genome, 10, 352-357 (1999). 10087291

Four strains of spontaneously hyperlipidemic (SHL) mice: phenotypic distinctions determined by genetic backgrounds.
Matsushima Y, Sakurai T, Ohoka A, Ohnuki T, Tada N, Asoh Y, Tachibana M
J. Atheroscler. Thromb., 8, 71-79 (2001). 11866033

The Lipid, 13, 318-324 (2002).

Health Report

Examination Date / Room / Rack2024/08/26Room:4-CRack:ASentinel mouse program
2024/05/27Room:4-CRack:ASentinel mouse program
2024/02/26Room:4-CRack:ASentinel mouse program
2023/11/27Room:4-CRack:ASentinel mouse program
2023/08/28Room:4-CRack:ASentinel mouse program
2023/05/29Room:4-CRack:ASentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Apoe
MGI:88057		apolipoprotein E7Apoe<shl>
MGI:3574899		spontaneous hyperlipidemia
  • age related macular degeneration 1(MedGEN)

  • Alzheimer disease 2(DisGeNET, MedGEN)

  • Alzheimer disease 3(MedGEN)
    • more 4 Diseases
  • Alzheimer disease 4(MedGEN)

  • hyperlipoproteinemia type 3(DisGeNET, MedGEN)

  • lipoprotein glomerulopathy(DisGeNET, MedGEN)

  • sea-blue histiocyte syndrome(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal circulating apolipoprotein E level(MP:0010333)

  • abnormal nursing(MP:0001382)

  • alopecia(MP:0000414)

  • atherosclerotic lesions(MP:0005338)

  • hyperlipidemia(MP:0001548)
    • more 4 phenotypes
  • increased circulating cholesterol level(MP:0005178)

  • increased susceptibility to atherosclerosis(MP:0005339)

  • premature death(MP:0002083)

  • xanthoma(MP:0003692)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationCardiovascular Research
    Hematological Research
    Mouse Models for Human Disease
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results.
    DepositorYoshibumi Matsushima (Saitama Cancer Center)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-
    Mouse of the Month Jan 2006

    BRC mice in Publications

    No Data