Strain Information | |
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Image | |
BRC No. | RBRC00144 |
Type | Congenic |
Species | Mus musculus |
Strain name | B6.SJL-Ptprc<a>/Rbrc |
Former Common name | C57BL/6-Ly-5.1 |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6 |
Appearance | black [a/a B/B C/C] |
Strain development | Deposited by Toshitada Takahashi, Aichi Cancer Center. |
Strain description | This is a B6 background congenic strain that having differential B cell antigen designated as Ly5.1. This strain is useful as tissue/cell and B cell markers in transplantation studies. |
Colony maintenance | Homozygote x Homozygote |
References |
Health Report | |
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Examination Date / Room / Rack | 2025/01/07Room:3-ARack:HSentinel mouse program 2024/10/07Room:3-ARack:HSentinel mouse program 2024/07/08Room:3-ARack:HSentinel mouse program 2024/04/08Room:3-ARack:HSentinel mouse program 2024/01/09Room:3-ARack:HSentinel mouse program 2023/10/10Room:3-ARack:HSentinel mouse program 2023/07/10Room:3-ARack:HSentinel mouse program 2023/04/10Room:3-ARack:HSentinel mouse program |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Ptprc MGI:97810 | protein tyrosine phosphatase receptor type C | 1 | Ptprc<a> MGI:4819849 | a variant |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data | ![]() |
Ordering Information | |
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Donor DNA | |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
Depositor | Toshitada Takahashi (Aichi Cancer Center) |
Strain Status | ![]() ![]() ![]() |
Strain Availability | Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (3 to 6 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month Jun 2009 |
BRC mice in Publications |
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Forgioni A, Watanabe M, Goto R, Harada T, Ota T, Shimamura T, Taketomi A. Anti-Inflammatory Effects of Ex Vivo-Generated Donor Antigen-Specific Immunomodulatory Cells on Pancreatic Islet Transplantation. Cell Transplant 34 9636897251317887(2025) 39981681 |
Srirat T, Hayakawa T, Mise-Omata S, Nakagawara K, Ando M, Shichino S, Ito M, Yoshimura A. NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment. Cell Rep 43(3) 113898(2024) 38451819 |
Yanagi M, Ikegami I, Kamekura R, Sato T, Sato T, Kamiya S, Murayama K, Jitsukawa S, Ito F, Yorozu A, Kihara M, Abe T, Takaki H, Kawata K, Shigehara K, Miyajima S, Nishikiori H, Sato A, Tohse N, Takano KI, Chiba H, Ichimiya S. Bob1 maintains T follicular helper cells for long-term humoral immunity. Commun Biol 7(1) 185(2024) 38360857 |
Mise-Omata S, Ando M, Srirat T, Nakagawara K, Hayakawa T, Iizuka-Koga M, Nishimasu H, Nureki O, Ito M, Yoshimura A. SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine. Cell Rep 112940(2023) 37582370 |
Takahiro Sano, Koki Ueda, Keiji Minakawa, Tsutomu Mori, Yuko Hashimoto, Haruhiko Koseki, Yasuchika Takeishi, Kazuhiko Ikeda, Takayuki Ikezoe Impaired Repopulating Ability of Uhrf2−/− Hematopoietic Progenitor Cells in Mice Genes 14 1531(2023) |
Sumii Y, Kondo T, Ikegawa S, Fukumi T, Iwamoto M, Nishimura MF, Sugiura H, Sando Y, Nakamura M, Meguri Y, Matsushita T, Tanimine N, Kimura M, Asada N, Ennishi D, Maeda Y, Matsuoka KI. Hematopoietic stem cell-derived Tregs are essential for maintaining favorable B cell lymphopoiesis following posttransplant cyclophosphamide. JCI Insight 8(8) (2023) 37092551 |
Suga K, Suto A, Tanaka S, Sugawara Y, Kageyama T, Ishikawa J, Sanayama Y, Ikeda K, Furuta S, Kagami SI, Iwata A, Hirose K, Suzuki K, Ohara O, Nakajima H. TAp63, a methotrexate target in CD4+ T cells, suppresses Foxp3 expression and exacerbates autoimmune arthritis. JCI Insight 8(10) (2023) 37212280 |
By Yukiko Tokifuji, Hodaka Hayabuchi, Takashi Sasaki, Mariko Hara-Chikuma, Keiji Hirota, Hayato Takahashi, Masayuki Amagai, Akihiko Yoshimura, Shunsuke Chikuma Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition iScience 108646(2023) |
Kondo T, Ikegawa S, Fukumi T, Sumii Y, Sugiura H, Sando Y, Nakamura M, Meguri Y, Iwamoto M, Maeda Y, Matsuoka KI. Pretransplant Short-Term Exposure of Donor Graft Cells to ITK Selective Inhibitor Ameliorates Acute Graft-versus-Host Disease by Inhibiting Effector T Cell Differentiation while Sparing Regulatory T Cells. Immunohorizons 5(6) 424-437(2021) 34112701 |
Hosaka N, Kanda S, Shimono T, Nishiyama T. Induction of γδT cells from HSC-enriched BMCs co-cultured with iPSC-derived thymic epithelial cells. J Cell Mol Med 25(22) 10604-10613(2021) 34687276 |
Kuroishi T, Bando K, Bakti RK, Ouchi G, Tanaka Y, Sugawara S. Migratory dendritic cells in skin-draining lymph nodes have nickel-binding capabilities. Sci Rep 10(1) 5050(2020) 32193426 |
Saijou E, Enomoto Y, Matsuda M, Yuet-Yin Kok C, Akira S, Tanaka M, Miyajima A. Neutrophils alleviate fibrosis in the CCl4-induced mouse chronic liver injury model. Hepatol Commun 2(6) 703-717(2018) 29881822 |
Uchiyama R, Yonehara S, Taniguchi S, Ishido S, Ishii KJ, Tsutsui H. Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo. J Immunol 199(3) 1122-1130(2017) 28674179 |
Tanaka Y, Nagashima H, Bando K, Lu L, Ozaki A, Morita Y, Fukumoto S, Ishii N, Sugawara S. Oral CD103-CD11b+ classical dendritic cells present sublingual antigen and induce Foxp3+ regulatory T cells in draining lymph nodes. Mucosal Immunol 10(1) 79-90(2017) 27166558 |
Matsumoto T, Sasaki N, Yamashita T, Emoto T, Kasahara K, Mizoguchi T, Hayashi T, Yodoi K, Kitano N, Saito T, Yamaguchi T, Hirata K. Overexpression of Cytotoxic T-Lymphocyte-Associated Antigen-4 Prevents Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol 36(6) 1141-51(2016) 27055906 |
Yo M, Sakaue-Sawano A, Noda S, Miyawaki A, Miyoshi H. Fucci-guided purification of hematopoietic stem cells with high repopulating activity. Biochem Biophys Res Commun 457(1) 7-11(2015) 25534850 |
Masuko K, Wakita D, Togashi Y, Kita T, Kitamura H, Nishimura T. Artificially synthesized helper/killer-hybrid epitope long peptide (H/K-HELP): preparation and immunological analysis of vaccine efficacy. Immunol Lett 163(1) 102-12(2015) 25479286 |
Omi A, Enomoto Y, Kiniwa T, Miyata N, Miyajima A. Mature resting Ly6C(high) natural killer cells can be reactivated by IL-15. Eur J Immunol 44(9) 2638-47(2014) 24995967 |
Iwata A, Kawashima S, Kobayashi M, Okubo A, Kawashima H, Suto A, Hirose K, Nakayama T, Nakajima H. Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity. Int Immunol 26(2) 103-14(2014) 24150243 |
Mise-Omata S, Alles N, Fukazawa T, Aoki K, Ohya K, Jimi E, Obata Y, Doi T. NF-κB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation. Int Immunol 26(11) 607-18(2014) 24908679 |
Nakashima K, Arai S, Suzuki A, Nariai Y, Urano T, Nakayama M, Ohara O, Yamamura K, Yamamoto K, Miyazaki T. PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression. Nat Commun 4 1836(2013) 23673621 |
Satoh T, Tajima M, Wakita D, Kitamura H, Nishimura T. The development of IL-17/IFN-γ-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter. Eur J Immunol 42(9) 2329-42(2012) 22674086 |
Tajima M, Wakita D, Satoh T, Kitamura H, Nishimura T. IL-17/IFN-γ double producing CD8+ T (Tc17/IFN-γ) cells: a novel cytotoxic T-cell subset converted from Tc17 cells by IL-12. Int Immunol 23(12) 751-9(2011) 22039016 |
Wada H, Kojo S, Kusama C, Okamoto N, Sato Y, Ishizuka B, Seino K. Successful differentiation to T cells, but unsuccessful B-cell generation, from B-cell-derived induced pluripotent stem cells. Int Immunol 23(1) 65-74(2011) 21135032 |
Inoue S, Noda S, Kashima K, Nakada K, Hayashi J, Miyoshi H. Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells. FEBS Lett 584(15) 3402-9(2010) 20600007 |
Mise-Omata S, Kuroda E, Sugiura T, Yamashita U, Obata Y, Doi TS. The NF-kappaB RelA subunit confers resistance to Leishmania major by inducing nitric oxide synthase 2 and Fas expression but not Th1 differentiation. J Immunol 182(8) 4910-6(2009) 19342670 |
Shimizu N, Noda S, Katayama K, Ichikawa H, Kodama H, Miyoshi H. Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G2/PA6. Int J Hematol 87(3) 239-45(2008) 18317883 |
Noda S, Horiguchi K, Ichikawa H, Miyoshi H. Repopulating activity of ex vivo-expanded murine hematopoietic stem cells resides in the CD48-c-Kit+Sca-1+lineage marker- cell population. Stem Cells 26(3) 646-55(2008) 18079432 |