Strain Data Sheet

RBRC00144

Strain Information

Image
BRC No.RBRC00144
TypeCongenic
SpeciesMus musculus
Strain nameB6.SJL-Ptprc<a>/Rbrc
Former Common nameC57BL/6-Ly-5.1
H-2 Haplotype
ES Cell line
Background strainC57BL/6
Appearanceblack [a/a B/B C/C]
Strain developmentDeposited by Toshitada Takahashi, Aichi Cancer Center.
Strain descriptionThis is a B6 background congenic strain that having differential B cell antigen designated as Ly5.1. This strain is useful as tissue/cell and B cell markers in transplantation studies.
Colony maintenanceHomozygote x Homozygote
References

Health Report

Examination Date / Room / Rack2025/01/07Room:3-ARack:HSentinel mouse program
2024/10/07Room:3-ARack:HSentinel mouse program
2024/07/08Room:3-ARack:HSentinel mouse program
2024/04/08Room:3-ARack:HSentinel mouse program
2024/01/09Room:3-ARack:HSentinel mouse program
2023/10/10Room:3-ARack:HSentinel mouse program
2023/07/10Room:3-ARack:HSentinel mouse program
2023/04/10Room:3-ARack:HSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ptprc
MGI:97810
protein tyrosine phosphatase receptor type C1Ptprc<a>
MGI:4819849
a variant

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • normal phenotype(MP:0002873)
  • Detailed phenotype dataPhenopub Link

    Ordering Information

    Donor DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorToshitada Takahashi (Aichi Cancer Center)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Live mouse (3 to 6 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-
    Mouse of the Month Jun 2009

    BRC mice in Publications

    Forgioni A, Watanabe M, Goto R, Harada T, Ota T, Shimamura T, Taketomi A.
    Anti-Inflammatory Effects of Ex Vivo-Generated Donor Antigen-Specific Immunomodulatory Cells on Pancreatic Islet Transplantation.
    Cell Transplant 34 9636897251317887(2025) 39981681
    Srirat T, Hayakawa T, Mise-Omata S, Nakagawara K, Ando M, Shichino S, Ito M, Yoshimura A.
    NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment.
    Cell Rep 43(3) 113898(2024) 38451819
    Yanagi M, Ikegami I, Kamekura R, Sato T, Sato T, Kamiya S, Murayama K, Jitsukawa S, Ito F, Yorozu A, Kihara M, Abe T, Takaki H, Kawata K, Shigehara K, Miyajima S, Nishikiori H, Sato A, Tohse N, Takano KI, Chiba H, Ichimiya S.
    Bob1 maintains T follicular helper cells for long-term humoral immunity.
    Commun Biol 7(1) 185(2024) 38360857
    Mise-Omata S, Ando M, Srirat T, Nakagawara K, Hayakawa T, Iizuka-Koga M, Nishimasu H, Nureki O, Ito M, Yoshimura A.
    SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine.
    Cell Rep 112940(2023) 37582370
    Takahiro Sano, Koki Ueda, Keiji Minakawa, Tsutomu Mori, Yuko Hashimoto, Haruhiko Koseki, Yasuchika Takeishi, Kazuhiko Ikeda, Takayuki Ikezoe
    Impaired Repopulating Ability of Uhrf2−/− Hematopoietic Progenitor Cells in Mice
    Genes 14 1531(2023)
    Sumii Y, Kondo T, Ikegawa S, Fukumi T, Iwamoto M, Nishimura MF, Sugiura H, Sando Y, Nakamura M, Meguri Y, Matsushita T, Tanimine N, Kimura M, Asada N, Ennishi D, Maeda Y, Matsuoka KI.
    Hematopoietic stem cell-derived Tregs are essential for maintaining favorable B cell lymphopoiesis following posttransplant cyclophosphamide.
    JCI Insight 8(8) (2023) 37092551
    Suga K, Suto A, Tanaka S, Sugawara Y, Kageyama T, Ishikawa J, Sanayama Y, Ikeda K, Furuta S, Kagami SI, Iwata A, Hirose K, Suzuki K, Ohara O, Nakajima H.
    TAp63, a methotrexate target in CD4+ T cells, suppresses Foxp3 expression and exacerbates autoimmune arthritis.
    JCI Insight 8(10) (2023) 37212280
    By Yukiko Tokifuji, Hodaka Hayabuchi, Takashi Sasaki, Mariko Hara-Chikuma, Keiji Hirota, Hayato Takahashi, Masayuki Amagai, Akihiko Yoshimura, Shunsuke Chikuma
    Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition
    iScience 108646(2023)
    Kondo T, Ikegawa S, Fukumi T, Sumii Y, Sugiura H, Sando Y, Nakamura M, Meguri Y, Iwamoto M, Maeda Y, Matsuoka KI.
    Pretransplant Short-Term Exposure of Donor Graft Cells to ITK Selective Inhibitor Ameliorates Acute Graft-versus-Host Disease by Inhibiting Effector T Cell Differentiation while Sparing Regulatory T Cells.
    Immunohorizons 5(6) 424-437(2021) 34112701
    Hosaka N, Kanda S, Shimono T, Nishiyama T.
    Induction of γδT cells from HSC-enriched BMCs co-cultured with iPSC-derived thymic epithelial cells.
    J Cell Mol Med 25(22) 10604-10613(2021) 34687276
    Kuroishi T, Bando K, Bakti RK, Ouchi G, Tanaka Y, Sugawara S.
    Migratory dendritic cells in skin-draining lymph nodes have nickel-binding capabilities.
    Sci Rep 10(1) 5050(2020) 32193426
    Saijou E, Enomoto Y, Matsuda M, Yuet-Yin Kok C, Akira S, Tanaka M, Miyajima A.
    Neutrophils alleviate fibrosis in the CCl4-induced mouse chronic liver injury model.
    Hepatol Commun 2(6) 703-717(2018) 29881822
    Uchiyama R, Yonehara S, Taniguchi S, Ishido S, Ishii KJ, Tsutsui H.
    Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo.
    J Immunol 199(3) 1122-1130(2017) 28674179
    Tanaka Y, Nagashima H, Bando K, Lu L, Ozaki A, Morita Y, Fukumoto S, Ishii N, Sugawara S.
    Oral CD103-CD11b+ classical dendritic cells present sublingual antigen and induce Foxp3+ regulatory T cells in draining lymph nodes.
    Mucosal Immunol 10(1) 79-90(2017) 27166558
    Matsumoto T, Sasaki N, Yamashita T, Emoto T, Kasahara K, Mizoguchi T, Hayashi T, Yodoi K, Kitano N, Saito T, Yamaguchi T, Hirata K.
    Overexpression of Cytotoxic T-Lymphocyte-Associated Antigen-4 Prevents Atherosclerosis in Mice.
    Arterioscler Thromb Vasc Biol 36(6) 1141-51(2016) 27055906
    Yo M, Sakaue-Sawano A, Noda S, Miyawaki A, Miyoshi H.
    Fucci-guided purification of hematopoietic stem cells with high repopulating activity.
    Biochem Biophys Res Commun 457(1) 7-11(2015) 25534850
    Masuko K, Wakita D, Togashi Y, Kita T, Kitamura H, Nishimura T.
    Artificially synthesized helper/killer-hybrid epitope long peptide (H/K-HELP): preparation and immunological analysis of vaccine efficacy.
    Immunol Lett 163(1) 102-12(2015) 25479286
    Omi A, Enomoto Y, Kiniwa T, Miyata N, Miyajima A.
    Mature resting Ly6C(high) natural killer cells can be reactivated by IL-15.
    Eur J Immunol 44(9) 2638-47(2014) 24995967
    Iwata A, Kawashima S, Kobayashi M, Okubo A, Kawashima H, Suto A, Hirose K, Nakayama T, Nakajima H.
    Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity.
    Int Immunol 26(2) 103-14(2014) 24150243
    Mise-Omata S, Alles N, Fukazawa T, Aoki K, Ohya K, Jimi E, Obata Y, Doi T.
    NF-κB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation.
    Int Immunol 26(11) 607-18(2014) 24908679
    Nakashima K, Arai S, Suzuki A, Nariai Y, Urano T, Nakayama M, Ohara O, Yamamura K, Yamamoto K, Miyazaki T.
    PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression.
    Nat Commun 4 1836(2013) 23673621
    Satoh T, Tajima M, Wakita D, Kitamura H, Nishimura T.
    The development of IL-17/IFN-γ-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter.
    Eur J Immunol 42(9) 2329-42(2012) 22674086
    Tajima M, Wakita D, Satoh T, Kitamura H, Nishimura T.
    IL-17/IFN-γ double producing CD8+ T (Tc17/IFN-γ) cells: a novel cytotoxic T-cell subset converted from Tc17 cells by IL-12.
    Int Immunol 23(12) 751-9(2011) 22039016
    Wada H, Kojo S, Kusama C, Okamoto N, Sato Y, Ishizuka B, Seino K.
    Successful differentiation to T cells, but unsuccessful B-cell generation, from B-cell-derived induced pluripotent stem cells.
    Int Immunol 23(1) 65-74(2011) 21135032
    Inoue S, Noda S, Kashima K, Nakada K, Hayashi J, Miyoshi H.
    Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells.
    FEBS Lett 584(15) 3402-9(2010) 20600007
    Mise-Omata S, Kuroda E, Sugiura T, Yamashita U, Obata Y, Doi TS.
    The NF-kappaB RelA subunit confers resistance to Leishmania major by inducing nitric oxide synthase 2 and Fas expression but not Th1 differentiation.
    J Immunol 182(8) 4910-6(2009) 19342670
    Shimizu N, Noda S, Katayama K, Ichikawa H, Kodama H, Miyoshi H.
    Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G2/PA6.
    Int J Hematol 87(3) 239-45(2008) 18317883
    Noda S, Horiguchi K, Ichikawa H, Miyoshi H.
    Repopulating activity of ex vivo-expanded murine hematopoietic stem cells resides in the CD48-c-Kit+Sca-1+lineage marker- cell population.
    Stem Cells 26(3) 646-55(2008) 18079432