Strain Data Sheet

RBRC00165

Strain Information

Image
BRC No.RBRC00165
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S4-Zic2<tm1Jaru>/JaruRbrc
Former Common nameC57BL/6N-Kd(Zic2), Zic2 Knockdown mouse
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strainC57BL/6N
Appearanceblack
Strain development
Strain description
Colony maintenance
References
Zic2 regulates the kinetics of neurulation.
Nagai T, Aruga J, Minowa O, Sugimoto T, Ohno Y, Noda T, Mikoshiba K
Proc. Natl. Acad. Sci. USA, 97, 1618-1623 (2000). 10677508

Zic2 controls cerebellar development in cooperation with Zic1.
Aruga J, Inoue T, Hoshino J, Mikoshiba K
J. Neurosci., 22, 218-225 (2002). 11756505

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Zic2
MGI:106679		zinc finger protein of the cerebellum 214Zic2<tm1Jaru>
MGI:2156825		targeted mutation 1, Jun Aruga
  • holoprosencephaly 5(DisGeNET, MedGEN)
    • neo neomycin resistance gene (E. coli)14 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal amygdala morphology(MP:0000818)

  • abnormal autopod morphology(MP:0000572)

  • abnormal brain development(MP:0000913)

  • abnormal cerebral cortex morphology(MP:0000788)

  • abnormal cerebral hemisphere morphology(MP:0008540)
    • more 40 phenotypes
  • abnormal dorsal root ganglion morphology(MP:0000961)

  • abnormal forebrain development(MP:0003232)

  • abnormal limb bone morphology(MP:0002115)

  • abnormal nervous system development(MP:0003861)

  • abnormal neural fold formation(MP:0004837)

  • abnormal neural plate morphology(MP:0005657)

  • abnormal neural tube morphology(MP:0002151)

  • abnormal olfactory bulb morphology(MP:0000819)

  • abnormal roof plate morphology(MP:0000923)

  • abnormal spatial learning(MP:0001463)

  • abnormal spatial working memory(MP:0008428)

  • abnormal spinal cord dorsal horn morphology(MP:0006282)

  • abnormal telencephalon development(MP:0000934)

  • abnormal vertebral arch morphology(MP:0004599)

  • anencephaly(MP:0001890)

  • behavior/neurological phenotype(MP:0005386)

  • curly tail(MP:0003051)

  • decreased aggression towards mice(MP:0003863)

  • decreased brain size(MP:0000774)

  • decreased corpus callosum size(MP:0000781)

  • decreased locomotor activity(MP:0001402)

  • decreased neuron number(MP:0008948)

  • decreased prepulse inhibition(MP:0009142)

  • enlarged lateral ventricles(MP:0008535)

  • exencephaly(MP:0000914)

  • fused carpal bones(MP:0008915)

  • fused metacarpal bones(MP:0004639)

  • fused metatarsal bones(MP:0004642)

  • fused tarsal bones(MP:0008919)

  • fusion of vertebral arches(MP:0004613)

  • hindlimb paralysis(MP:0000755)

  • holoprosencephaly(MP:0005157)

  • hyperactivity(MP:0001399)

  • impaired contextual conditioning behavior(MP:0009454)

  • impaired cued conditioning behavior(MP:0009456)

  • increased startle reflex(MP:0001488)

  • microcephaly(MP:0000433)

  • postnatal lethality, complete penetrance(MP:0011085)

  • spina bifida(MP:0003054)

  • thin cerebral cortex(MP:0006254)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Zic2 (Zic finger protein of the cerebellum 2) genomic DNA
    Research applicationNeurobiology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 97, 1618-1623 (2000).
    DepositorJun Aruga (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP

    BRC mice in Publications

    Barnada SM, Giner de Gracia A, Morenilla-Palao C, López-Cascales MT, Scopa C, Waltrich FJ Jr, Mikkers HMM, Cicardi ME, Karlin J, Trotti D, Peterson KA, Brugmann SA, Santen GWE, McMahon SB, Herrera E, Trizzino M.
    ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial-to-mesenchymal transition in cranial neural crest specification.
    Am J Hum Genet 111(10) 2232-2252(2024) 39226899
    Sánchez-Arrones L, Nieto-Lopez F, Sánchez-Camacho C, Carreres MI, Herrera E, Okada A, Bovolenta P.
    Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina.
    J Neurosci 33(20) 8596-607(2013) 23678105
    García-Frigola C, Herrera E.
    Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets.
    EMBO J 29(18) 3170-83(2010) 20676059
    García-Frigola C, Carreres MI, Vegar C, Mason C, Herrera E.
    Zic2 promotes axonal divergence at the optic chiasm midline by EphB1-dependent and -independent mechanisms.
    Development 135(10) 1833-41(2008) 18417618