Strain Data Sheet

RBRC00186

Strain Information

Image
BRC No.RBRC00186
TypeInbred
SpeciesMus musculus
Strain nameDDK/Nga
Former Common name
H-2 Haplotype
ES Cell line
Background strainDDK
Appearancealbino [A/A B/B c/c D/D]
Strain developmentDeveloped by Dr. Kyoji Kondo at Nagoya University, School of Agriculture in 1944. Derived from outbred dd stock from Institute Infectious Diseases, Universtiy of Tokyo.
Strain descriptionDerived from outbred dd stock from Institute Infectious Diseases, Universtiy of Tokyo. The DDK females mated to C57BL males are semi-sterile, but the reciprocal cross is fully fertile.
Colony maintenanceSibling Mating
References
A genetically determined incompatibility system between spermatozoa and eggs leading to embryonic death in mice.
Wakasugi N
J. Reprod. Fertil., 41, 85-96 (1974). 4431024

Characterization and chromosomal distribution of endogenous mouse mammary tumor viruses of European mouse strains STS/A and GR/A.
Michalides R, Verstraeten R, Shen F W, Hilgers J
Virology, 142, 278-290 (1985). 2997987

The locus Om, responsible for the DDK syndrome, maps close to Sigje on mouse chromosome 11.
Baldacci P A, Richoux V, Renard J P, Guenet J L, Babinet C
Mamm. Genome, 2, 100-105 (1992). 1347470

Tcrb-V3+ T-cell deletion and a new mouse mammary tumor provirus, Mtv-44.
Fairchild S, Rosenwasser O A, Dyson P J, Tomonari K
Immunogenetics, 36, 189-194 (1992). 1319398

A maternal factor affecting mouse blastocyst formation.
Renard J P, Baldacci P, Richoux-Duranthon V, Pournin S, Babinet C
Development, 120, 797-802 (1994). 7541334

Female mice of DDK strain are fully fertile in the intersubspecific crosses with Mus musculus molossinus and M. m. castaneus.
Zhao W D, Ishikawa A, Yamagata T, Bolor H, Wakasugi N
Mamm. Genome, 13, 345-351 (2002). 12140682

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Om
MGI:97434		ovum mutant11Om
Omlr
MGI:2149847		om-linked responder11Omlr

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal embryo development (MP:0001672)

  • abnormal female meiosis (MP:0005168)

  • abnormal trophoblast layer morphology (MP:0005031)

  • embryonic lethality before implantation, incomplete penetrance (MP:0011104)

  • maternal effect (MP:0003718)
    • more 2 phenotypes
  • reduced female fertility (MP:0001923)

  • transmission ratio distortion (MP:0004179)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDevelopmental Biology Research
    Immunology and Inflammation Research
    Reproductive Biology Research
    Virology Research
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorNoboru Wakasugi (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data