Strain Data Sheet

RBRC00197

Strain Information

Image
BRC No.RBRC00197
TypeInbred
SpeciesMus musculus
Strain nameIITES
Former Common nameII-TES
H-2 Haplotype
ES Cell line
Background strainIITES
Appearancedilute brown, piebald [a/a b/b C/C d/d P/P s/s]
Strain developmentDeveloped by Dr. Kyoji Kondo at Nagoya University, School of Agriculture. Originally mixed background of CS, DBA/2, NC and ITES strains.
Strain descriptionThese mice have 4 autosomal recessive coat color genes (a/a b/b d/d s/s) and are useful for testing color genes.
Colony maintenanceSibling Mating (Homozygote x Homozygote)
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ednrb
MGI:102720		endothelin receptor type B14Ednrb<s>
MGI:1856148		piebald
  • ABCD syndrome(MedGEN)

  • Hirschsprung disease, susceptibility to, 2(MedGEN)

  • Waardenburg syndrome type 4A(MedGEN)
    • a
    MGI:87853    		nonagouti2a<a>
    MGI:1855937    		nonagouti
    Tyrp1
    MGI:98881    		tyrosinase-related protein 14Tyrp1<b>
    MGI:1855960    		brown
  • oculocutaneous albinism type 3(MedGEN)
    • Oca2
    MGI:97454    		oculocutaneous albinism II7Oca2<p>
    MGI:1856114    		pink-eyed dilution
  • oculocutaneous albinism type 2(DisGeNET, MedGEN)
    • Myo5a
    MGI:105976    		myosin VA9Myo5a<d>
    MGI:1856004    		dilute
  • Griscelli syndrome type 1(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal coat/hair pigmentation(MP:0002075)

  • abnormal dorsoventral coat patterning(MP:0008238)

  • abnormal foot pigmentation(MP:0009379)

  • abnormal hair shaft melanin granule distribution(MP:0008733)

  • abnormal hair shaft melanin granule morphology(MP:0008731)
    • more 14 phenotypes
  • abnormal iris morphology(MP:0001322)

  • abnormal melanocyte morphology(MP:0002877)

  • abnormal tail pigmentation(MP:0005174)

  • darkened coat color(MP:0005409)

  • decreased body size(MP:0001265)

  • decreased eye pigmentation(MP:0005172)

  • endocrine/exocrine gland phenotype(MP:0005379)

  • enlarged hair follicle melanin granules(MP:0005071)

  • iris atrophy(MP:0006228)

  • megacolon(MP:0002731)

  • reduced hair shaft melanin granule number(MP:0008732)

  • variable body spotting(MP:0002940)

  • variable depigmentation(MP:0010016)

  • white spotting(MP:0002938)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and Conditions
    DepositorMasahiko Nishimura (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    Osipova DV, Kulikov AV, Mekada K, Yoshiki A, Moshkin MP, Kotenkova EV, Popova NK.
    Distribution of the C1473G polymorphism in tryptophan hydroxylase 2 gene in laboratory and wild mice.
    Genes Brain Behav 9(5) 537-43(2010) 20398061