Strain Data Sheet

RBRC00388

Strain Information

Image
BRC No.RBRC00388
TypeSpontaneous Mutation
SpeciesMus musculus
Strain namePROD-Cacna1a<tg-rol>/NemOdaRbrc
Former Common namePROD-rol/+
H-2 Haplotype
ES Cell line
Background strain
Appearanceagouti with white spot [A/A B/? C/C s/s]
Strain developmentDeveloped by Dr. Sen-ichi Oda, Nagoya University. Cacna1a<tg-rol> arose spontaneously in descendants of (SIII x C57BL/6)F1 in 1969.
Strain descriptionRolling mouse Nagoya, PROD-Cacna1a<tg-rol>/NemOdaRbrc. Cacna1a gene is a voltage-gated pore-forming membrane protein, mediates Ca2+ influx across presynaptic and somatodendritic membranes, thereby triggering fast neurotransmitter release and other key neuronal responses. Homozygous mutant mice exhibit a severe ataxia, episodic dyskinesia, and cerebellar atrophy.
Colony maintenanceHomozygous mutant mice are identifiable between 10 and 14 days old by a creeping or rolling gait.homozygous females are fertile but do not breed well.
References
実験動物, 22, 281-288 (1973).

名古屋大学環境医学研究所年報, 26, 7-9 (1975).

名古屋大学環境医学研究所年報, 27, 193-194 (1976).

名古屋大学環境医学研究所年報, 27, 195-197 (1976).

医学のあゆみ, 101, 74-75 (1977).

名古屋大学環境医学研究所年報, 28, 212-213 (1977).

Biomed. Res., 1, 88-90 (1980).

Jpn. J. Genet., 56, 295-299 (1981).

Genetic Approches to Developmental Neurobiology (TSUKADA Yasuzo, ed), University of Tokyo Press, Tokyo, pp. 171-181 (1982).

実験動物の遺伝的コントロール（富田武，江崎考三郎，早川純一郎，編）ソフトサイエンス社，　東京， pp. 248-259 (1983).
more 5 references
Postnatal locomotion development in a neurological mutant of rolling mouse Nagoya.
Tamaki Y, Oda S, Kameyama Y
Dev. Psycobiology, 19, 67-77 (1986). 3699253

Neurotransmitter receptors of the rolling mouse Nagoya: a quantitative autoradiographic study.
Onodera H, Takase S, Oda S, Sobue I, Kogure K
Neurosci. Res., 5, 316-324 (1988). 2897649

Morphologic investigation of rolling mouse Nagoya (tg(rol)/tg(rol)) cerebellar Purkinje cells: an ataxic mutant, revisited.
Rhyu I J, Oda S, Uhm C S, Kim H, Suh Y S, Abbott L C
Neurosci. Lett., 266, 49-52 (1999). 10336181

チャンネル病, 脳の科学(1999年増刊号), 星和書店, 東京, 101-106 (1999).

Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol)).
Mori Y, Wakamori M, Oda S, Fletcher C F, Sekiguchi N, Mori E, Copeland N G, Jenkins N A, Matsushita K, Matsuyama Z, Imoto K
J. Neurosci., 20, 5654-5662 (2000). 10908603

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cacna1a
MGI:109482		calcium channel, voltage-dependent, P/Q type, alpha 1A subunit8Cacna1a<tg-rol>
MGI:1856211		rolling Nagoya
  • developmental and epileptic encephalopathy, 42(MedGEN)

  • episodic ataxia type 2(DisGeNET, MedGEN)

  • migraine, familial hemiplegic, 1(MedGEN)
    • more 1 Diseases
  • spinocerebellar ataxia type 6(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal CNS synaptic transmission(MP:0002206)

  • abnormal amino acid level(MP:0005332)

  • abnormal brainstem morphology(MP:0005277)

  • abnormal cerebellum morphology(MP:0000849)

  • abnormal enzyme/coenzyme activity(MP:0005584)
    • more 27 phenotypes
  • abnormal excitatory postsynaptic currents(MP:0002910)

  • abnormal glucose homeostasis(MP:0002078)

  • abnormal metabolism(MP:0005266)

  • abnormal miniature excitatory postsynaptic currents(MP:0004753)

  • abnormal muscle electrophysiology(MP:0004145)

  • abnormal nervous system physiology(MP:0003633)

  • abnormal noradrenaline level(MP:0003964)

  • abnormal nursing(MP:0001382)

  • abnormal response/metabolism to endogenous compounds(MP:0003638)

  • ataxia(MP:0001393)

  • cerebellum atrophy(MP:0014185)

  • cerebellum hypoplasia(MP:0000851)

  • decreased body weight(MP:0001262)

  • decreased choline O-acetyltransferase activity(MP:0012590)

  • decreased glutamic acid level(MP:0030737)

  • enhanced paired-pulse facilitation(MP:0002919)

  • impaired limb coordination(MP:0001524)

  • increased apoptosis(MP:0006042)

  • increased brain tyrosine 3-monooxygenase activity(MP:0020076)

  • increased glycine level(MP:0030658)

  • increased noradrenaline level(MP:0012575)

  • increased taurine level(MP:0030635)

  • muscle weakness(MP:0000747)

  • reduced female fertility(MP:0001923)

  • reduced male fertility(MP:0001922)

  • small cerebellum(MP:0000852)

  • weakness(MP:0000746)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDevelopmental Biology Research
    Genetics Research
    Mouse Models for Human Disease
    Neurobiology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorSenichi Oda (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    Kim TY, Niimi K, Takahashi E.
    Analysis of the protective effects of the α2/δ subunit of voltage-gated Ca2+ channels in brain injury.
    Brain Res 1655 138-144(2017) 27840189
    Niimi K, Han Y, Zhou Y, Yoshimoto T, Dai F, Teng X, Tian X, Li W, Takahashi E.
    Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction.
    Behav Brain Res 259 45-9(2014) 24177210
    Tian X, Zhou Y, Gao L, He G, Jiang W, Li W, Takahashi E.
    Analysis of ischemic neuronal injury in Cav2.1 channel α1 subunit mutant mice.
    Biochem Biophys Res Commun 434(1) 60-4(2013) 23545255
    Fukumoto N, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
    Ca2+ channel currents in dorsal root ganglion neurons of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya.
    Neurosci Res 73(3) 199-206(2012) 22575052
    Takahashi E, Niimi K, Itakura C.
    Interaction between Ca(v)2.1alpha (1) and CaMKII in Ca (v)2.1alpha (1) mutant mice, Rolling Nagoya.
    J Mol Neurosci 41(2) 223-9(2010) 19609731
    Takahashi E, Niimi K, Itakura C.
    Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya.
    Behav Brain Res 204(1) 241-5(2009) 19467269
    Takahashi E, Niimi K, Itakura C.
    Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice.
    Brain Res 1279 50-7(2009) 19446536
    Takahashi E, Niimi K.
    Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya.
    Exp Gerontol 44(4) 274-9(2009) 19073246
    Fukumoto N, Obama Y, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
    Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya.
    Neuroscience 160(1) 165-73(2009) 19248821
    Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M.
    Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.
    Blood 107(3) 1078-84(2006) 16219795