Strain Data Sheet

RBRC00407

Strain Information

Image
BRC No.RBRC00407
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Tcrd<tm1Mom>/ItoRbrc
Former Common nameTCR delta-KO, TCRd KO
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. S. Itohara, P. Mombaerts and S Tonegawa, Howard Hughes Medical Institute, Massachusetts Institute of Technology in 1993.
Strain descriptionDeveloped by Drs. S. Itohara, P. Mombaerts and S Tonegawa, Howard Hughes Medical Institute, Massachusetts Institute of Technology in 1993.
Colony maintenanceSibling MatingHomozygous mutant mice are viable and fertile.
References
T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes.
Itohara S, Mombaerts P, Lafaille J, Iacomini J, Nelson A, Clarke A R, Hooper M L, Farr A, Tonegawa S
Cell, 72, 337-348 (1993). 8381716

Health Report

Examination Date / Room / Rack2024/05/07Room:2-検Rack:GSentinel mouse program
2024/02/05Room:2-検Rack:GSentinel mouse program
2023/11/06Room:2-検Rack:GSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tcrd
MGI:98611		T cell receptor delta chain14Tcrd<tm1Mom>
MGI:1857257		targeted mutation 1, Peter Mombaerts
neo neomycin resistance gene (E. coli)14 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal gamma-delta T cell differentiation(MP:0008356)

  • abnormal respiratory system physiology(MP:0002133)

  • abnormal skin condition(MP:0001191)

  • absent gamma-delta T cells(MP:0008348)

  • dermatitis(MP:0001194)
    • more 2 phenotypes
  • impaired skin barrier function(MP:0002796)

  • increased apoptosis(MP:0006042)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse T-cell receptor delta chain genome DNA
    Research applicationCell Biology Research
    Immunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell, 72, 337-348 (1993).
    DepositorShigeyoshi Itohara (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Segawa S, Goto D, Iizuka A, Kaneko S, Yokosawa M, Kondo Y, Matsumoto I, Sumida T.
    The regulatory role of interferon-γ producing gamma delta T cells via the suppression of T helper 17 cell activity in bleomycin-induced pulmonary fibrosis.
    Clin Exp Immunol 185(3) 348-60(2016) 27083148
    Segawa S, Goto D, Yoshiga Y, Horikoshi M, Sugihara M, Hayashi T, Chino Y, Matsumoto I, Ito S, Sumida T.
    Involvement of NK 1.1-positive γδT cells in interleukin-18 plus interleukin-2-induced interstitial lung disease.
    Am J Respir Cell Mol Biol 45(3) 659-66(2011) 21257923