Strain Data Sheet
RBRC00432
Strain Information | |
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| Image |  |
| BRC No. | RBRC00432 |
| Type | Spontaneous Mutation |
| Species | Mus musculus |
| Strain name | RLC/Stm |
| Former Common name | RLC/Stm |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | RLC/Stm |
| Appearance | albino |
| Strain development | Spontaneous mutation originally arose in CXSN/A strain. The mutant mice were bred with a BALB/cHeA and then maintained by inbreeding. |
| Strain description | rlc, Rupture of Lens Cataract. Spontaneous recessive mutation arose in CXSN/A mice. The mutation as a deletion of 27 bp at the end of 15th of Dock5 gene. |
| Colony maintenance | |
| References | Mapping of rupture of lens cataract (rlc) on mouse chromosome 14. Matsushima Y, Kamoto T, Iida F, Abujiang P, Honda Y, Hiai H Genomics, 36, 553-554 (1996). 8884285Rupture of lens cataract: a novel hereditary recessive cataract model in the mouse. Iida F, Matsushima Y, Hiai H, Uga S, Honda Y Exp. Eye Res., 64, 107-113 (1997). 9093026Morphological study on rupture of posterior capsule in RLC mouse lens. Teramoto Y, Uga S, Matsushima Y, Shimizu K, Morita T, Shirakawa S Graefe's Arch. Clin. Exp. Ophthalmol., 238, 970-978 (2000). 11196360 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Dock5 MGI:2652871 | dedicator of cytokinesis 5 | 14 | Dock5<rlc> MGI:1861664 | rupture of lens cataract | |||
Phenotype | |
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| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | |
| Research application | Mouse Models for Human Disease Sensorineural Research |
| Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
| Depositor | Yoshibumi Matsushima (Saitama Cancer Center) |
| Strain Status |  Frozen embryos |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
| Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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Omi N, Kiyokawa E, Matsuda M, Kinoshita K, Yamada S, Yamada K, Matsushima Y, Wang Y, Kawai J, Suzuki M, Hayashizaki Y, Hiai H. Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse. Exp Eye Res 86(5) 828-34(2008) 18396277 |
Hiai H, Tsuruyama T, Yamada Y. Pre-B lymphomas in SL/Kh mice: a multifactorial disease model. Cancer Sci 94(10) 847-50(2003) 14556656 |