Strain Data Sheet

RBRC00442

Strain Information

Image
BRC No.RBRC00442
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Nbl1<tm1Saki>/SakiRbrc
Former Common nameDAN Knockout mice
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strainC57BL/6NCrlCrlj
Appearanceblack
Strain development
Strain description
Colony maintenance
References
Cloning of mouse DAN cDNA and its down-regulation in transformed cells.
Ozaki T, Ma J, Takenaga K, Sakiyama S
Jpn. J. Cancer Res., 87, 58-61 (1996). 8609050

Tumor-Suppressing Viruses, Genes and Drugs Innovative Cancer Therapy Approaches, 221-231 (2002).

Reduced inflammatory pain in mice deficient in the differential screening-selected gene aberrative in neuroblastoma.
Ohtori S, Isogai E, Hasue F, Ozaki T, Nakamura Y, Nakagawara A, Koseki H, Yuasa S, Hanaoka E, Shinbo J, Yamamoto T, Chiba H, Yamazaki M, Moriya H, Sakiyama S
Mol. Cell Neurosci., 25(3):504-14 (2004). 15033178

Health Report

Examination Date / Room / Rack2025/01/20Room:3-CRack:ISentinel mouse program
2024/10/21Room:3-CRack:ISentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Nbl1
MGI:104591		NBL1, DAN family BMP antagonist4Nbl1<tm1Saki>
MGI:3042574		targeted mutation 1, S Sakiyama
neo neomycin resistance gene (E. coli)4 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal pain threshold(MP:0001970)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Nbl1 genomic DNA
    Research application
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorShigeru Sakiyama (Chiba Cancer Center)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Live mouse (3 to 6 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data