Strain Data Sheet

RBRC00614

Strain Information

Image
BRC No.RBRC00614
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6By.Cg-Sox18<Ra> Pt Os/JMs
Former Common nameC57BL/6By-RaOsPt/+
H-2 Haplotype
ES Cell line
Background strainC57BL/6By
Appearance
Strain development
Strain description
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Sox18
MGI:103559		SRY (sex determining region Y)-box 182Sox18<Ra>
MGI:1856135		ragged
  • hypotrichosis-lymphedema-telangiectasia syndrome(MedGEN)

  • hypotrichosis-lymphedema-telangiectasia-renal defect syndrome(MedGEN)
    • Pt
    MGI:97790    		pintail4Pt
    MGI:1861192
    Os
    MGI:97446    		oligosyndactylism8Os
    MGI:1857646

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal calcaneum morphology (MP:0009728)

  • abnormal carpal bone morphology (MP:0000554)

  • abnormal caudal vertebrae morphology (MP:0002759)

  • abnormal embryonic autopod plate morphology (MP:0004576)

  • abnormal embryonic tissue morphology (MP:0002085)
    • more 54 phenotypes
  • abnormal hair follicle morphology (MP:0000377)

  • abnormal kidney collecting duct morphology (MP:0004754)

  • abnormal kidney collecting duct principal cell morphology (MP:0011757)

  • abnormal kidney morphology (MP:0002135)

  • abnormal limb bud morphology (MP:0005650)

  • abnormal limb mesenchyme morphology (MP:0011261)

  • abnormal mitosis (MP:0004046)

  • abnormal navicular morphology (MP:0009727)

  • abnormal nephron morphology (MP:0003881)

  • abnormal notochord morphology (MP:0002825)

  • abnormal nucleus pulposus morphology (MP:0006392)

  • abnormal proximal convoluted tubule morphology (MP:0004756)

  • abnormal renal glomerulus morphology (MP:0005325)

  • abnormal tail morphology (MP:0002111)

  • abnormal tail tip morphology (MP:0013177)

  • abnormal tarsal bone morphology (MP:0005104)

  • abnormal zigzag hair morphology (MP:0000402)

  • absent auchene hairs (MP:0006363)

  • alopecia (MP:0000414)

  • chylous ascites (MP:0012080)

  • darkened coat color (MP:0005409)

  • decreased body size (MP:0001265)

  • decreased caudal vertebrae number (MP:0001539)

  • decreased compensatory renal growth (MP:0002956)

  • decreased embryo size (MP:0001698)

  • decreased kidney weight (MP:0003918)

  • decreased renal glomerulus number (MP:0004505)

  • decreased survivor rate (MP:0008770)

  • decreased total body fat amount (MP:0010025)

  • edema (MP:0001785)

  • embryonic growth arrest (MP:0001730)

  • embryonic lethality between implantation and placentation, complete penetrance (MP:0011095)

  • expanded mesangial matrix (MP:0011353)

  • fused carpal bones (MP:0008915)

  • fused tarsal bones (MP:0008919)

  • glomerulonephritis (MP:0002743)

  • glomerulosclerosis (MP:0005264)

  • increased blood urea nitrogen level (MP:0005565)

  • increased mitotic index (MP:0004760)

  • increased urine flow rate (MP:0011431)

  • intestinal fibrosis (MP:0011748)

  • kinked tail (MP:0000585)

  • oligodactyly (MP:0000565)

  • polydactyly (MP:0000562)

  • polysyndactyly (MP:0004083)

  • prenatal lethality (MP:0002080)

  • preweaning lethality, incomplete penetrance (MP:0011110)

  • renal tubule hypertrophy (MP:0011408)

  • retarded hair growth (MP:0000424)

  • short tail (MP:0000592)

  • small intervertebral disk (MP:0004682)

  • small notochord (MP:0004710)

  • sparse hair (MP:0000416)

  • syndactyly (MP:0000564)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshihiko Shiroishi (National Institute of Genetics)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data