Strain Information | |
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Image | ![]() |
BRC No. | RBRC00757 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | B6;129P2-Ptpn7<tm1Bwz>/Rbrc |
Former Common name | HePTP Knockout mice |
H-2 Haplotype | |
ES Cell line | E14K [129P2/OlaHsd] |
Background strain | C57BL/6JJcl |
Appearance | black [a/a B/B C/C] |
Strain development | B6;129P2-Ptpn7<tm1Bwz>. Hematopoietic protein tyrosine phosphatase (HePTP) is a hematopoiesis-specific cytoplasmic protein tyrosine phosphatase that is induced in primary lymphocytes by extracellular stimuli. This knockout mouse strain is useful for investigating the function of the HePTP gene. |
Strain description | Developed by Dr. Haruhiko Suzuki, University of Toronto in 1994. A neomycin selection cassette was inserted into the second exon of the HePTP gene. The HePTP deficient mice were backcrossed to C57BL/6 for 4 times. |
Colony maintenance | Homozygous mutant mice were viable and fertile. |
References | Hematopoietic protein tyrosine phosphatase suppresses extracellular stimulus-regulated kinase activation. Gronda M, Arab S, Iafrate B, Suzuki H, Zanke B W Mol. Cell. Biol., 21, 6851-6858 (2001). 11564869 |
Health Report | |
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Examination Date / Room / Rack | 2024/10/07Room:3-BRack:JSentinel mouse program 2024/07/08Room:3-BRack:JAdditional tests 2024/04/08Room:3-BRack:JSentinel mouse program 2024/01/09Room:3-BRack:JSentinel mouse program 2023/10/10Room:3-BRack:JSentinel mouse program 2023/07/10Room:3-BRack:JSentinel mouse program 2023/04/10Room:3-BRack:JSentinel mouse program |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Ptpn7 MGI:2156893 | protein tyrosine phosphatase, non-receptor type 7 | 1 | Ptpn7<tm1Bwz> MGI:2178956 | targeted mutation 1, Brent W Zanke | |||
neo | neomycin resistance gene (E. coli) | 1 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Ptpn7 genomic DNA |
Research application | |
Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
Depositor | Haruhiko Suzuki (Nagoya University) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Wang N, Langfelder P, Stricos M, Ramanathan L, Richman JB, Vaca R, Plascencia M, Gu X, Zhang S, Tamai TK, Zhang L, Gao F, Ouk K, Lu X, Ivanov LV, Vogt TF, Lu QR, Morton AJ, Colwell CS, Aaronson JS, Rosinski J, Horvath S, Yang XW. Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. Neuron 110(20) 3318-3338.e9(2022) 36265442 |