Strain Data Sheet

RBRC00758

Strain Information

Image
BRC No.RBRC00758
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Map2k6<tm1Ina>/Rbrc
Former Common nameMKK6 Knockout mice
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainC57BL/6J and 129P2/OlaHsd mixed
Appearanceblack [a/a B/B C/C]
Strain development
Strain description
Colony maintenance
References
Involvement of MKK6 in TCRalphabeta(int)CD69lo: a target population for apoptotic cell death in thymocytes.
Suzuki H, Wu J, Hossain K, Ohhata T, Du J, Akhand A A, Hayakawa A, Kimura H, Hagiwara M, Nakashima I
FASEB J., 17, 1538-1540 (2003). 12824301

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Map2k6
MGI:1346870		mitogen-activated protein kinase kinase 611Map2k6<tm1Ina> targeted mutation 1, Izumi Nakashima
neo neomycin resistance gene (E. coli)11 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • decreased apoptosis(MP:0006043)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse MKK6 genomic DNA, E. coli neo, mouse phosphoglycerate kinase promoter (PGK promoter)
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The users must disclose the research plan using this resource to the depositor in advance.
    DepositorHaruhiko Suzuki (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Contact Information
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data