Strain Data Sheet

RBRC00872

Strain Information

Image
BRC No.RBRC00872
TypeChromosomal Aberration
SpeciesMus musculus
Strain nameSTOCK XO Eda<Ta>/O/Rbrc
Former Common nameXO
H-2 Haplotype
ES Cell line
Background strain
Appearanceagouti with mosaic striped coat [X<Ta>/X]
agouti with tabby [X<Ta>/X<Ta>, X<Ta>/Y]
Strain developmentDeposited by Dr. Nobuo Takagi, Hokkaido University.
Strain descriptionStrain with monosomic X choromosomal aberration (X/O). This strain also has tabby (Eda<Ta>) mutation that affects both the coat color and hair pattern growth. The mice having X<Ta>/O or X<Ta>/Y show yellow coat, no hair on ears and tail, bald patch behind ears, and no guard hairs. Meanwhile, X<Ta>/X females show agouti with mosaic striped due to X-inactivation.agouti with tabby (yellow coat, no hair on ears and tail, bald patch behind ears, no guard hairs) (X<Ta>/X<Ta>, X<Ta>/Y); agouti with mosaic striped coat (X<Ta>/X)
Colony maintenanceThis strain is maintained using tabby as a phenotypic marker to keep monosomic X chromosome condition. When wild-type female (X/O) is bred to hemizygote tabby male (X<Ta>/Y) in the first generation, hemizygote tabby female (X<Ta>/O) is bred to wild-type male (X/Y) in the second generation. On the contrary, when hemizygote tabby female (X<Ta>/O) is bred to wild-type male (X/Y) in the first generation, wild-type female (X/O) is bred to hemizygote male (X<Ta>/Y) in the second generation.
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Eda
MGI:1195272		ectodysplasin-AXEda<Ta>
MGI:1856197		tabby
  • tooth agenesis, selective, X-linked, 1(MedGEN)

  • X-linked hypohidrotic ectodermal dysplasia(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal coat appearance(MP:0001510)

  • abnormal coat/ hair morphology(MP:0000367)

  • abnormal coat/hair pigmentation(MP:0002075)

  • abnormal cornea epithelium morphology(MP:0006000)

  • abnormal cornea morphology(MP:0001312)
    • more 45 phenotypes
  • abnormal eye morphology(MP:0002092)

  • abnormal eyelid margin morphology(MP:0013745)

  • abnormal eyelid morphology(MP:0001340)

  • abnormal guard hair morphology(MP:0000397)

  • abnormal hair follicle development(MP:0003704)

  • abnormal hair follicle melanocyte morphology(MP:0004381)

  • abnormal hair follicle pheomelanosome pheomelanin content(MP:0006370)

  • abnormal hair growth(MP:0002073)

  • abnormal hair texture(MP:0002074)

  • abnormal lateral nasal gland morphology(MP:0013582)

  • abnormal molar cusp morphology(MP:0030457)

  • abnormal molar root morphology(MP:0030494)

  • abnormal nasal cavity morphology(MP:0002237)

  • abnormal nasal gland morphology(MP:0013580)

  • abnormal nose morphology(MP:0002233)

  • abnormal palatal rugae morphology(MP:0009652)

  • abnormal respiratory system morphology(MP:0002132)

  • abnormal skeleton morphology(MP:0005508)

  • abnormal skin pigmentation(MP:0002095)

  • abnormal tail morphology(MP:0002111)

  • abnormal tail ring morphology(MP:0012078)

  • abnormal tail tip morphology(MP:0013177)

  • abnormal vibrissa number(MP:0009003)

  • absent Meibomian glands(MP:0006236)

  • absent guard hair(MP:0006365)

  • absent hair follicle pheomelanosome pheomelanin(MP:0006371)

  • absent vibrissae(MP:0001284)

  • absent zigzag hairs(MP:0006366)

  • blepharitis(MP:0005251)

  • conjunctivitis(MP:0001852)

  • cornea opacity(MP:0001314)

  • cornea vascularization(MP:0005542)

  • corneal limbitis(MP:0013478)

  • decreased zigzag hair amount(MP:0008538)

  • eye inflammation(MP:0001851)

  • focal hair loss(MP:0000418)

  • hairless tail(MP:0010233)

  • increased incidence of corneal inflammation(MP:0001313)

  • irregular coat pigmentation(MP:0000372)

  • kinked tail(MP:0000585)

  • narrow eye opening(MP:0005287)

  • striated fur(MP:0009659)

  • thin epidermis(MP:0001218)

  • thin skin(MP:0001199)

  • transverse fur striping(MP:0010231)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorNobuo Takagi (Hokkaido University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityLive mouse (3 to 6 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Miura K, Murata C, Harikae K, Suzuki H, Kanai-Azuma M, Kurohmaru M, Tsunekawa N, Kanai Y.
    Defects in the first wave of folliculogenesis in mouse XO ovaries.
    J Reprod Dev 63(3) 333-338(2017) 28392504