Strain Data Sheet

RBRC00894

Strain Information

Image
BRC No.RBRC00894
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(CAG-Aicda)B1Hon/HonRbrc
Former Common nameAID-Tg line #B1
H-2 Haplotype
ES Cell line
Background strainC57BL/6NCrSlc
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Drs. Tasuku Honjo and Il-mi Okazaki at Kyoto University in 2002.
Strain descriptionAID, Activation-Induced cytidine Deaminase is a molecule which specifically expressed in B lymphocytes after antigen stimulation, and plays a central role in acquisition for B cell of antibody gene variety. The transgenic mice express mouse AID gene under the control of CAG promoter and show high incidence of T cell lymphomas and dysgenetic lesions of epithelium of respiratory bronchioles.
Colony maintenanceBackcross to C57BL/6 (Hemizygote x C57BL/6CrSlc)
References
Constitutive expression of AID leads to tumorigenesis.
Okazaki I M, Hiai H, Kakazu N, Yamada S, Muramatsu M, Kinoshita K, Honjo T
J. Exp. Med., 197, 1173-1181 (2003). 12732658

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Aicda
MGI:1342279		activation-induced cytidine deaminaseUNAicda CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
  • hyper-IgM syndrome type 2(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal gut flora balance(MP:0010377)

  • abnormal lung adenoma incidence(MP:0020190)

  • abnormal lymphopoiesis(MP:0002401)

  • abnormal thymus size(MP:0002364)

  • decreased CD4-positive, alpha-beta T cell number(MP:0008075)
    • more 12 phenotypes
  • decreased CD8-positive, alpha-beta T cell number(MP:0008079)

  • decreased birth body size(MP:0009703)

  • enlarged lymph nodes(MP:0000702)

  • enlarged spleen(MP:0000691)

  • epidermal cyst(MP:0003414)

  • immune system phenotype(MP:0005387)

  • increased lung adenocarcinoma incidence(MP:0002027)

  • increased lymphoma incidence(MP:0012431)

  • increased susceptibility to bacterial infection induced morbidity/mortality(MP:0009788)

  • increased susceptibility to bacterial infection(MP:0002412)

  • large lymphoid organs(MP:0002220)

  • small thymus(MP:0000706)
    • Detailed phenotype data

    Ordering Information

    Donor DNACAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), mouse Aicda cDNA
    Research applicationImmunology and Inflammation Research
    Specific Term and Conditions1) The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results.
    2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR are requested. J. Exp. Med., 197, 1173-1181 (2003).
    3) RECIPIENT shall notify the PROVIDER upon filing a patent application claiming modification of the BIOLOGICAL RESOURCE or method(s) of manufacture or use(s) of the BIOLOGICAL RESOURCE.
    DepositorTasuku Honjo (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. CAGGS MTA (English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Honjo Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data