Strain Data Sheet

RBRC00896

Strain Information

Image
BRC No.RBRC00896
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(CAG-Aicda,CAG-EGFP)C1Hon/HonRbrc
Former Common nameAID-Tg line #C1
H-2 Haplotype
ES Cell line
Background strainC57BL/6NCrSlc
Appearance
Strain development
Strain description
Colony maintenance
References
Constitutive expression of AID leads to tumorigenesis.
Okazaki I M, Hiai H, Kakazu N, Yamada S, Muramatsu M, Kinoshita K, Honjo T
J. Exp. Med., 197, 1173-1181 (2003). 12732658

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Aicda
MGI:1342279		activation-induced cytidine deaminaseUNAicda CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
  • hyper-IgM syndrome type 2(MedGEN)
    • GFP Green Fluorescent Protein (Aequorea victoria)UN CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal gut flora balance(MP:0010377)

  • abnormal lung adenoma incidence(MP:0020190)

  • abnormal lymphopoiesis(MP:0002401)

  • abnormal thymus size(MP:0002364)

  • decreased CD4-positive, alpha-beta T cell number(MP:0008075)
    • more 12 phenotypes
  • decreased CD8-positive, alpha-beta T cell number(MP:0008079)

  • decreased birth body size(MP:0009703)

  • enlarged lymph nodes(MP:0000702)

  • enlarged spleen(MP:0000691)

  • epidermal cyst(MP:0003414)

  • immune system phenotype(MP:0005387)

  • increased lung adenocarcinoma incidence(MP:0002027)

  • increased lymphoma incidence(MP:0012431)

  • increased susceptibility to bacterial infection induced morbidity/mortality(MP:0009788)

  • increased susceptibility to bacterial infection(MP:0002412)

  • large lymphoid organs(MP:0002220)

  • small thymus(MP:0000706)
    • Detailed phenotype data

    Ordering Information

    Donor DNACAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), mouse Aicda cDNA, Jellyfish GFP cDNA
    Research applicationCancer Research
    Fluorescent Proteins/lacZ System
    Immunology and Inflammation Research
    Specific Term and Conditions1) The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results.
    2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR are requested. J. Exp. Med., 197, 1173-1181 (2003).
    3) RECIPIENT shall notify the PROVIDER upon filing a patent application claiming modification of the BIOLOGICAL RESOURCE or method(s) of manufacture or use(s) of the BIOLOGICAL RESOURCE.
    DepositorTasuku Honjo (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. CAGGS MTA (English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Honjo Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data