Strain Data Sheet

RBRC00958

Strain Information

Image
BRC No.RBRC00958
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Stat6<tm1Aki>/AkiRbrc
Former Common nameSTAT6 KO
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strainC57BL/6NJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Essential role of Stat6 in IL-4 signalling.
Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, Nakanishi K, Yoshida N, Kishimoto T, Akira S
Nature, 380, 627-630 (1996). 8602263

Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IkappaBzeta-/- mice.
Ueta M, Hamuro J, Ueda E, Katoh N, Yamamoto M, Takeda K, Akira S, Kinoshita S
Invest. Ophthalmol. Vis. Sci., 49, 3387-3394 (2008). 18441309

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Stat6
MGI:103034		signal transducer and activator of transcription 610Stat6<tm1Aki>
MGI:2386746		targeted mutation 1, Shizuo Akira
neo neomycin resistance gene (E. coli)10 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal T-helper 2 physiology(MP:0005466)

  • acanthosis(MP:0001874)

  • decreased B cell proliferation(MP:0005093)

  • decreased IgE level(MP:0002492)

  • decreased IgG1 level(MP:0008495)
    • more 5 phenotypes
  • decreased T cell proliferation(MP:0005095)

  • decreased T-helper 2 cell number(MP:0008091)

  • increased IgA level(MP:0002495)

  • increased IgG level(MP:0002493)

  • skin inflammation(MP:0004947)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse STAT6 genomic DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 380, 627-630 (1996).
    DepositorShizuo Akira (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data