Strain Data Sheet

RBRC00969

Strain Information

Image
BRC No.RBRC00969
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(CD2-Tbx21)727Staka/StakaRbrc
Former Common nameVA T-bet line727
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Transcription factors T-bet and GATA-3 regulate development of airway remodeling.
Kiwamoto T, Ishii Y, Morishima Y, Yoh K, Maeda A, Ishizaki K, Iizuka T, Hegab A E, Matsuno Y, Homma S, Nomura A, Sakamoto T, Takahashi S, Sekizawa K
Am. J. Crit. Care. Med., 174, 142-151 (2006). 16614350

Th1 and type 1 cytotoxic T cells dominate responses in T-bet overexpression transgenic mice that develop contact dermatitis.
Ishizaki K, Yamada A, Yoh K, Nakano T, Shimohata H, Maeda A, Fujioka Y, Morito N, Kawachi Y, Shibuya K, Otsuka F, Shibuya A, Takahashi S
J. Immunol., 178, 605-612 (2007). 17182601

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tbx21
MGI:1888984		T-box 21UNTbx21 human CD2 promoter enhancer
  • asthma, nasal polyps, and aspirin intolerance(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal type IV hypersensitivity reaction(MP:0002534)

  • decreased IgE level(MP:0002492)

  • decreased IgG level(MP:0001805)

  • decreased IgG2a level(MP:0008496)

  • decreased interleukin-5 secretion(MP:0008703)
    • more 3 phenotypes
  • dermatitis(MP:0001194)

  • increased IgG1 level(MP:0008499)

  • increased circulating interferon-gamma level(MP:0008577)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman CD2 promoter enhancer, mouse T-bet cDNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorSatoru Takahashi (University of Tsukuba)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-
    Mouse of the Month Feb 2008

    BRC mice in Publications

    No Data