Strain Data Sheet

RBRC00993

Strain Information

Image
BRC No.RBRC00993
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S4-Sh2b3<tm1Rmp>/Rbrc
Former Common nameC57BL/6 Lnk -/-
H-2 Haplotype
ES Cell lineAK7 [129S4/SvJaeSor]
Background strainC57BL/6JJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins.
Takaki S, Sauer K, Iritani B M, Chien S, Ebihara Y, Tsuji K, Takatsu K, Perlmutter R M
Immunity, 13, 599-609 (2000). 11114373

Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome.
Guris D L, Fantes J, Tara D, Druker B J, Imamoto A
Nat. Genet., 27, 293-298 (2001). 11242111

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Sh2b3
MGI:893598		SH2B adaptor protein 35Sh2b3<tm1Rmp>
MGI:2180088		targeted mutation 1 Roger M. Perlmutter
  • myelofibrosis(MedGEN)

  • primary familial polycythemia due to EPO receptor mutation(MedGEN)

  • thrombocythemia 1(MedGEN)
    • neo neomycin resistance gene (E. coli)5 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal activation-induced B cell apoptosis(MP:0010669)

  • abnormal hematopoietic stem cell morphology(MP:0004808)

  • abnormal spleen size(MP:0002224)

  • enlarged spleen(MP:0000691)

  • increased B cell number(MP:0005014)
    • more 5 phenotypes
  • increased IgM level(MP:0002494)

  • increased bone marrow cell number(MP:0000321)

  • increased immature B cell number(MP:0008214)

  • increased myeloid cell number in bone marrow(MP:0013415)

  • increased splenocyte number(MP:0009338)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Lnk genomic DNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Immunity 13, 599-609 (2000). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The depositor should be a co-author in the articles when the users publish their data using these mice for 1 year after provided.
    Users should contact the depositor in the case of application for any patents with the results from these mice.
    DepositorSatoshi Takaki (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Zhu X, Fang J, Jiang DS, Zhang P, Zhao GN, Zhu X, Yang L, Wei X, Li H.
    Exacerbating Pressure Overload-Induced Cardiac Hypertrophy: Novel Role of Adaptor Molecule Src Homology 2-B3.
    Hypertension 66(3) 571-81(2015) 26101343