Strain Data Sheet

RBRC01042

Strain Information

Image
BRC No.RBRC01042
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Trim27<tm1Sis>/Rbrc
Former Common nameRfp (ret finger protein) Knockout mice
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates tumor necrosis factor alpha-induced apoptosis.
Zaman M M, Nomura T, Takagi T, Okamura T, Jin W, Shinagawa T, Tanaka Y, Ishii S
Mol. Cell. Biol., 33(24):4971-4984 (2013). 24144979

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Trim27
MGI:97904		tripartite motif-containing 2713Trim27<tm1Sis> targeted mutation 1, Shunsuke Ishii
neo neomycin resistance gene (E. coli)13 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • decreased circulating alanine transaminase level(MP:0002942)

  • decreased circulating aspartate transaminase level(MP:0005632)

  • decreased hepatocyte apoptosis(MP:0008891)

  • decreased sensitivity to induced cell death(MP:0008944)

  • decreased susceptibility to induced morbidity/mortality(MP:0009764)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli neo, mouse Trim27 genomic DNA, mouse phosphoglycerate kinase promoter (PGK promoter)
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Cell. Biol., 33(24):4971-4984 (2013). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorShunsuke Ishii (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data