Strain Data Sheet

RBRC01044

Strain Information

Image
BRC No.RBRC01044
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC.Cg-Crebbp<tm1Sis>/Rbrc
Former Common nameCBP Knockout mice
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainBALB/cCrSlc
Appearance
Strain development
Strain description
Colony maintenance
References
Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome.
Tanaka Y, Naruse I, Maekawa T, Masuya H, Shiroishi T, Ishii S
Proc. Natl. Acad. Sci. USA, 94, 10215-10220 (1997). 9294190

Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein.
Tanaka Y, Naruse I, Hongo T, Xu M, Nakahata T, Maekawa T, Ishii S
Mech. Dev., 95, 133-145 (2000). 10906457

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Crebbp
MGI:1098280		CREB binding protein16Crebbp<tm1Sis>
MGI:1928768		targeted mutation 1, Shunsuke Ishii
  • Menke-Hennekam syndrome 1(MedGEN)

  • Rubinstein-Taybi syndrome due to CREBBP mutations(MedGEN)

  • Rubinstein-Taybi syndrome(DisGeNET)
    • neo neomycin resistance gene (E. coli)16

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal blood vessel morphology(MP:0001614)

  • abnormal extraembryonic tissue morphology(MP:0002086)

  • abnormal forebrain morphology(MP:0000783)

  • abnormal joint morphology(MP:0002932)

  • abnormal limb morphology(MP:0002109)
    • more 30 phenotypes
  • abnormal mesenchyme morphology(MP:0006301)

  • abnormal neural tube closure(MP:0003720)

  • abnormal neural tube morphology(MP:0002151)

  • abnormal rib morphology(MP:0000150)

  • abnormal spinal cord morphology(MP:0000955)

  • abnormal sternum morphology(MP:0000157)

  • abnormal thoracic vertebrae morphology(MP:0003047)

  • abnormal vasculogenesis(MP:0001622)

  • abnormal vertebrae morphology(MP:0000137)

  • asymmetric sternocostal joints(MP:0008146)

  • decreased angiogenesis(MP:0005602)

  • decreased embryo size(MP:0001698)

  • delayed bone ossification(MP:0000060)

  • embryonic growth retardation(MP:0003984)

  • embryonic lethality during organogenesis, complete penetrance(MP:0011098)

  • embryonic lethality, complete penetrance(MP:0011092)

  • exencephaly(MP:0000914)

  • impaired hematopoiesis(MP:0001606)

  • incomplete rostral neuropore closure(MP:0000928)

  • increased thoracic vertebrae number(MP:0004651)

  • intracranial hemorrhage(MP:0001915)

  • large anterior fontanelle(MP:0000085)

  • oligodactyly(MP:0000565)

  • open neural tube(MP:0000929)

  • pale yolk sac(MP:0001722)

  • pallor(MP:0003717)

  • postnatal growth retardation(MP:0001732)

  • prenatal lethality, incomplete penetrance(MP:0011101)

  • scoliosis(MP:0000161)

  • xiphoid process foramen(MP:0004679)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli neo, mouse CREB binding protein genomic DNA
    Research applicationDevelopmental Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 94, 10215-10220 (1997). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorShunsuke Ishii (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data