Strain Data Sheet

RBRC01048

Strain Information

Image
BRC No.RBRC01048
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Atf7<tm1Sis>/Rbrc
Former Common nameATFa Knock out
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene.
Maekawa T, Kim S, Nakai D, Makino C, Takagi T, Ogura H, Yamada K, Chatton B, Ishii S
EMBO J., 29(1):196-208 (2010). 19893493

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Atf7
MGI:2443472		activating transcription factor 715Atf7<tm1Sis> targeted mutation 1, Shunsuke Ishii
neo neomycin resistance gene (E. coli)15

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • decreased prepulse inhibition(MP:0009142)

  • increased anxiety-related response(MP:0001363)

  • increased startle reflex(MP:0001488)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Atfa (activating transcription factor) genomic DNA
    Research applicationCancer Research
    Cell Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO J., 29(1):196-208 (2010). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorShunsuke Ishii (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data