Strain Data Sheet

RBRC01080

Strain Information

Image
BRC No.RBRC01080
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Drd1a<tm1Mok>
Former Common nameD1R KO, B6-D1R KO
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences.
Strain descriptionD1R (Ded1a) gene knockout mice.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
References
Dopamine D1 receptor modulates hippocampal representation plasticity to spatial novelty.
Tran A H, Uwano T, Kimura T, Hori E, Katsuki M, Nishijo H, Ono T
J. Neurosci., 28(50):13390-13400 (2008). 19074012

Distinct motor impairments of dopamine D1 and D2 receptor knockout mice revealed by three types of motor behavior.
Nakamura T, Sato A, Kitsukawa T, Momiyama T, Yamamori T, Sasaoka T
Front Integr Neurosci., 8, 56 (2014). 25076876

Expression pattern of immediate early genes in the cerebellum of D1R KO, D2R KO, and wild type mice under vestibular-controlled activity.
Nakamura T, Sato A, Kitsukawa T, Sasaoka T, Yamamori T
Front Cell Dev Biol., 3, 38 (2015). 26137459

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Drd1
MGI:99578		dopamine receptor D113Drd1<tm1Mok>
MGI:3829942		targeted mutation 1, Motoya Katsuki
Ecogpt E.coli xanthine phosphoribosyltransferase13Ecogpt mouse phosphoglycerate kinase promoter (PGK promoter)
neo neomycin resistance gene (E. coli)13 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal cognition(MP:0014114)

  • abnormal synaptic plasticity(MP:0004859)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli xanthine phosphoribosyltransferase(Ecogpt), herpes simplex virus thymidine kinase promoter (HSV tk promoter), E coli neo, mouse dopamine receptor1 genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 28(50):13390-13400 (2008). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-
    Mouse of the Month Oct 2009

    BRC mice in Publications

    Nagatomo K, Suga S, Saitoh M, Kogawa M, Kobayashi K, Yamamoto Y, Yamada K.
    Dopamine D1 Receptor Immunoreactivity on Fine Processes of GFAP-Positive Astrocytes in the Substantia Nigra Pars Reticulata of Adult Mouse.
    Front Neuroanat 11 3(2017) 28203148
    Hu Z, Oh EH, Chung YB, Hong JT, Oh KW.
    Predominant D1 Receptors Involvement in the Over-expression of CART Peptides after Repeated Cocaine Administration.
    Korean J Physiol Pharmacol 19(2) 89-97(2015) 25729269
    Nguyen CL, Tran AH, Matsumoto J, Hori E, Uwano T, Ono T, Nishijo H.
    Hippocampal place cell responses to distal and proximal cue manipulations in dopamine D2 receptor-knockout mice.
    Brain Res 1567 13-27(2014) 24747614