Strain Data Sheet
RBRC01081
Strain Information | |
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| Image |  |
| BRC No. | RBRC01081 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | B6.129S-Drd2<tm1Mok> |
| Former Common name | D2R KO, B6-D2R KO |
| H-2 Haplotype | |
| ES Cell line | CCE/EK.CCE [129S/SvEv-Gpi1<c>] |
| Background strain | |
| Appearance | black |
| Strain development | Developed by Motoya Katsuki, National Institutes of Natural Sciences (Medical Institute of Bioregulation, Kyushu University). |
| Strain description | D2R (Drd2) gene knockout mice. |
| Colony maintenance | Heterozygote x Wild-type [C57BL/6JJcl] |
| References | Genes Cells, 1, 253-268 (1996). 9140068 Front Cell Dev Biol., 3, 38 (2015). 26137459 Front Integr Neurosci., 8, 56 (2014). 25076876 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)9neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Ordering Information | |
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| Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse dopamine receptor2 genomic DNA |
| Research application | Neurobiology Research |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Cells. 1, 253-68, (1996). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
| Depositor | Toshikuni Sasaoka (Niigata University) |
| Strain Status |  Frozen embryos Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Shioda N, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabe M, Sasahara M, Fukunaga K. Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons. Mol Psychiatry 22(8) 1205-1222(2017) 27922607 Wakabayashi C, Numakawa T, Ooshima Y, Hattori K, Kunugi H. Possible role of the dopamine D1 receptor in the sensorimotor gating deficits induced by high-fat diet. Psychopharmacology (Berl) 232(24) 4393-400(2015) 26359228 |