Strain Data Sheet

RBRC01082

Strain Information

Image
BRC No.RBRC01082
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Drd3<tm1Mok>
Former Common nameD3R KO, B6-D3R KO
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Motoya Katsuki, National Institutes of Natural Sciences.
Strain descriptionD3R (Drd3) gene knockout mice.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Drd3
MGI:94925		dopamine receptor D316Drd3<tm1Mok>
MGI:6376625		targeted mutation 1, Motoya Katsuki
  • schizophrenia(MedGEN)

  • tremor, hereditary essential, 1(MedGEN)
    • Ecogpt E.coli xanthine phosphoribosyltransferase16Ecogpt mouse phosphoglycerate kinase promoter (PGK promoter)
    neo neomycin resistance gene (E. coli)16 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E.coli xanthine phosphoribosyltransferase(Ecogpt), herpes simplex virus thymidine kinase promoter (HSV tk promoter), E coli neo, mouse Drd3 genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. 未定In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshikuni Sasaoka (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Masaki Matsuda, Takumi Nishi, Yuya Yoshida, Yuma Terada, Chihiro Matsuda-Hayama, Taishei Kumamoto, Kengo Hamamura, Eriko Kohro-ikeda, Shinobu Yasuo, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo
    Dopamine receptor D3 affects the expression of Period1 in mouse cells via DRD3–ERK–CREB signaling.
    Biochemical and Biophysical Research Communications 151470(2025) 39954359