Strain Information | |
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Image | |
BRC No. | RBRC01089 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129S-Nras<tm1Mok> |
Former Common name | N-ras KO, B6-Nras KO |
H-2 Haplotype | |
ES Cell line | CCE/EK.CCE [129S/SvEv-Gpi1<c>] |
Background strain | C57BL/6 |
Appearance | |
Strain development | Developed by Motoya Katsuki, National Institutes of Natural Sciences (Institute of Medical Science, University of Tokyo). |
Strain description | Nras gene knockout mice. Homozygous mutant mice show no obvious abnormality. |
Colony maintenance | Heterozygote x Wild-type [C57BL/6JJcl] |
References | K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development. Matsui T, Kinoshita T, Morikawa Y, Tohya K, Katsuki M, Ito Y, Kamiya A, Miyajima A EMBO J. 21(5):1021-30 (2002). 11867530K-ras is essential for the development of the mouse embryo. Koera K, Nakamura K, Nakao K, Miyoshi J, Toyoshima K, Hatta T, Otani H, Aiba A, Katsuki M Oncogene, 15, 1151-1159 (1997). 9294608Partial functional overlap of the three ras genes in mouse embryonic development. Nakamura K, Ichise H, Nakao K, Hatta T, Otani H, Sakagami H, Kondo H, Katsuki M Oncogene, 27, 2961-2968 (2008). 18059342 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Csde1 | cold shock domain containing E1, RNA binding | 3 | Csde1 | ||||
Nras | neuroblastoma ras oncogene | 3 | Nras | targeted mutation 1, Motoya Katsuki | |||
neo | neomycin resistance gene (E. coli) | 3 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E coli neo, mouse N-ras genomic DNA, mouse Csde1 genomic DNA |
Research application | Cancer Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO J., 21, 1021-1030 (2002). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Toshikuni Sasaoka (Niigata University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |