Strain Data Sheet

RBRC01146

Strain Information

Image
BRC No.RBRC01146
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameICR.Cg-Mesp1<tm3Ysa>/YsaRbrc
Former Common nameMesp1-v1
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainICR MCH
Appearance
Strain development
Strain description
Colony maintenance
References
Genetic rescue of segmentation defect in MesP2-deficient mice by MesP1 gene replacement.
Saga Y
Mech. Dev., 75, 53-66 (1998). 9739106

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mesp1
MGI:107785		mesoderm posterior 17Mesp1<tm3Ysa>
MGI:2182080		targeted mutation 3, Yumiko Saga
neo neomycin resistance gene (E. coli)7 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal cardiogenic mesoderm morphology(MP:0012278)

  • abnormal heart development(MP:0000267)

  • abnormal heart looping(MP:0000269)

  • abnormal heart tube morphology(MP:0000270)

  • abnormal mesoderm development(MP:0001680)
    • more 15 phenotypes
  • abnormal neural fold formation(MP:0004837)

  • abnormal neural tube morphology(MP:0002151)

  • abnormal paraxial mesoderm morphology(MP:0008029)

  • abnormal primitive streak morphology(MP:0002231)

  • abnormal somite size(MP:0005222)

  • cardia bifida(MP:0004187)

  • decreased embryo size(MP:0001698)

  • decreased somite size(MP:0011732)

  • delayed embryo turning(MP:0004188)

  • delayed neural tube closure(MP:0002621)

  • embryonic growth arrest(MP:0001730)

  • embryonic growth retardation(MP:0003984)

  • embryonic lethality during organogenesis, complete penetrance(MP:0011098)

  • failure of initiation of embryo turning(MP:0004180)

  • microcephaly(MP:0000433)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Mesp1 genomic DNA
    Research applicationDevelopmental Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mech. Dev., 75, 53-66 (1998).
    DepositorYumiko Saga (National Institute of Genetics)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Saga Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data