Strain Data Sheet

RBRC01152

Strain Information

Image
BRC No.RBRC01152
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S7-Hey2<tm1Kkb>/YsaRbrc
Former Common namehairy and enhancer of split-related 2
H-2 Haplotype
ES Cell lineAB1 [129S7/SvEvBrd-Hprt<+>]
Background strainC57BL/6NJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction.
Kokubo H, Miyagawa-Tomita S, Tomimatsu H, Nakashima Y, Nakazawa M, Saga Y, Johnson R L
Circ Res. 95, 540-547 (2004). 15297376

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Hey2
MGI:1341884		hairy/enhancer-of-split related with YRPW motif 210Hey2<tm1Kkb>
MGI:3574394		targeted mutation 1, Hiroki Kokubo
loxP phage P1 loxP10loxP
loxP phage P1 loxP10loxP
neo neomycin resistance gene (E. coli)10 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal Z line morphology(MP:0004091)

  • abnormal aortic valve cusp morphology(MP:0010595)

  • abnormal atrioventricular valve morphology(MP:0002745)

  • abnormal endocardium morphology(MP:0003974)

  • abnormal mitral valve morphology(MP:0000286)
    • more 34 phenotypes
  • abnormal myocardial fiber morphology(MP:0000278)

  • abnormal myocardium layer morphology(MP:0005329)

  • abnormal pulmonary alveolus morphology(MP:0002270)

  • abnormal pulmonary valve cusp morphology(MP:0010602)

  • abnormal semilunar valve morphology(MP:0002746)

  • abnormal tricuspid valve morphology(MP:0002624)

  • abnormal ventricle myocardium morphology(MP:0010499)

  • aortic valve regurgitation(MP:0006047)

  • aortic valve stenosis(MP:0006117)

  • atrioventricular valve regurgitation(MP:0006046)

  • cardiac fibrosis(MP:0003141)

  • congestive heart failure(MP:0006138)

  • decreased heart rate(MP:0005333)

  • decreased heart ventricle muscle contractility(MP:0005598)

  • dilated heart atrium(MP:0003140)

  • dilated heart left ventricle(MP:0002753)

  • dilated heart right ventricle(MP:0002754)

  • enlarged heart(MP:0000274)

  • increased heart weight(MP:0002833)

  • increased lung weight(MP:0005630)

  • liver vascular congestion(MP:0010019)

  • mitral valve regurgitation(MP:0006045)

  • ostium secundum atrial septal defect(MP:0010405)

  • perimembraneous ventricular septal defect(MP:0010418)

  • postnatal growth retardation(MP:0001732)

  • postnatal lethality, complete penetrance(MP:0011085)

  • premature death(MP:0002083)

  • pulmonary edema(MP:0003828)

  • pulmonary vascular congestion(MP:0010018)

  • respiratory distress(MP:0001954)

  • thick aortic valve(MP:0010594)

  • thick pulmonary valve(MP:0010601)

  • tricuspid valve regurgitation(MP:0006044)

  • tricuspid valve stenosis(MP:0006124)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse hairy and enhancer of split-related 2 genomic DNA
    Research applicationCell Biology Research
    Developmental Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Circ Res. 95, 540-547 (2004).
    DepositorYumiko Saga (National Institute of Genetics)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Saga Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data