Strain Data Sheet

RBRC01172

Strain Information

Image
BRC No.RBRC01172
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Hivep1<tm1Sis>/Rbrc
Former Common nameShn-1 KO B6, Schnurri-1(Shn-1) Knockout mice -B6
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainC57BL/6JJcl
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Tsuyoshi Takagi, Laboratory of Molecular Genetics, RIKEN Tsukuba Institute in 1998.
Strain descriptionB6.Cg-Shn1<tm1Sis>. Schnurri-1 knock-out mice.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
References
HIVEP1 Is a Negative Regulator of NF-κB That Inhibits Systemic Inflammation in Sepsis.
Hisatake Matsumoto, Brendon P Scicluna, Kin Ki Jim, Fahimeh Falahi, Wanhai Qin, Berke Gürkan, Erik Malmström, Mariska T Meijer, Joe M Butler, Hina N Khan, Tsuyoshi Takagi, Shunsuke Ishii, Marcus J Schultz, Diederik van de Beek, Alex F de Vos, Cornelis van 't Veer, Tom van der Poll
Front Immunol., 12:744358 (2021). 34804025

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Hivep1
MGI:96100		human immunodeficiency virus type I enhancer binding protein 113Hivep1<tm1Sis>
MGI:5494144		targeted mutation 1, Shunsuke Ishii
neo neomycin resistance gene (E. coli)13 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Schnurri-1 genomic DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Front Immunol., 12:744358 (2021). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorShunsuke Ishii (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data