Strain Information | |
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Image | |
BRC No. | RBRC01188 |
Type | Transgene![]() |
Species | Mus musculus |
Strain name | B6.Cg-Tg(CTSG-NUP98/HOXA9)1589Tanak/TanakRbrc |
Former Common name | t(7;11)AML NUP98-HOXA9 transgenic (Tg) mice |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Dr. Kakuro Nakamura, NIH in 1996. The transgene was injected into the pronuclei of B6D2F2 fertilized eggs. The transgenic mice were backcrossed to C57BL/6J over 10 times. |
Strain description | B6.Cg-Tg(CTSG-NUP98/HOXA9)1589Tanak. This transgenic mice express the chimeric NUP98-HOXA9 gene in the myeloid lineage. About 20% of mice with this transgene exhibit myeloproliferative disorder and acute myeloid leukemia (AML). |
Colony maintenance | Carrier x Noncarrier [C57BL/6JJcl] |
References | Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model. Iwasaki M, Kuwata T, Yamazaki Y, Jenkins N A, Copeland N G, Osato M, Ito Y, Kroon E, Sauvageau G, Nakamura T Blood, 105, 784-793 (2005). 15454493 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
CTSG | Cathepsin G (human) | UN | CTSG | ||||
HOXA9 | homeo box A9 (human) | UN | HOXA9 | ||||
NUP98 | nucleoporin 98 (human) | UN | NUP98 | human Cathepsin G promoter |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | human Cathepsin G genomic DNA, human NUP98-HOXA9 cDNA |
Research application | Cancer Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. |
Depositor | Takuro Nakamura (Japanese Foundation for Cancer Research) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month Mar 2006 |
BRC mice in Publications |
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Funasaka T, Nakano H, Wu Y, Hashizume C, Gu L, Nakamura T, Wang W, Zhou P, Moore MA, Sato H, Wong RW. RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis. Cell Cycle 10(9) 1456-67(2011) 21467841 |