Strain Data Sheet

RBRC01202

Strain Information

Image
BRC No.RBRC01202
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameSTOCK Ttf/t<w5>+/ArtRbrc
Former Common nameTtf/t<w5>, STOCK Ttf/t<w5>+/ArtRbrc
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentFrom Sloan Kettering-mice have been maintained@Univ.Tx@Austin since 1984
Strain descriptionLitters usually 3-6 pups -but can have more.
Colony maintenanceParental cage : 2 males x 3 females - always better to have two males if possible, for max. breeding-one become dominant, other subordinate, three females, always one preg, efficiency even though zero tailed=A
References
Genetic Change in Mutations at the T/t-Locus in the Mouse.
Bennett D, Dunn L C, Artzt K
Genetics, 83, 361-372 (1976). 17248720

The molecular organization of the H-2K region of two t-haplotypes: implications for the evolution of genetic diversity.
Uehara H, Abe K, Park C H, Shin H S, Bennett D, Artzt K
EMBO J., 6, 83-90 (1987). 3034582

Intra-H-2 recombination in t haplotypes shows a hot spot and close linkage of 1tw5 to H-2K.
Artzt K, Abe K, Uehara H, Bennett D
Immunogenetics, 28, 30-37 (1988). 3378835

Molecular identification of t(w5): Vps52 promotes pluripotential cell differentiation through cell-cell interactions.
Sugimoto M, Kondo M, Hirose M, Suzuki M, Mekada K, Abe T, Kiyonari H, Ogura A, Takagi N, Artzt K, Abe K
Cell Rep., 2(5) 1363-74 (2012). 23142660

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Itpr3
MGI:96624		inositol 1,4,5-triphosphate receptor 317Itpr3<tf>
MGI:1857070		tufted
  • type 1 diabetes mellitus(MedGEN)
    • T
    MGI:98472    		brachyury, T-box transcription factor T17T
    MGI:1856184    		brachyury
  • neural tube defect(MedGEN)

  • sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome(MedGEN)
    • Vps52
    MGI:1330304    		VPS52 GARP complex subunit17Vps52<t-w5>
    MGI:5469352    		t, wild 5

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal allogrooming behavior (MP:0011000)

  • abnormal blastocyst morphology (MP:0004957)

  • abnormal brain commissure morphology (MP:0002199)

  • abnormal cerebral cortex morphology (MP:0000788)

  • abnormal coat/ hair morphology (MP:0000367)
    • more 62 phenotypes
  • abnormal colon morphology (MP:0000495)

  • abnormal dorsal aorta morphology (MP:0004787)

  • abnormal ectoderm development (MP:0001675)

  • abnormal epidermal layer morphology (MP:0001216)

  • abnormal forelimb bud morphology (MP:0013164)

  • abnormal gustatory system physiology (MP:0001985)

  • abnormal hair cycle (MP:0000427)

  • abnormal hair growth (MP:0002073)

  • abnormal head shape (MP:0011495)

  • abnormal heart looping (MP:0000269)

  • abnormal heart tube morphology (MP:0000270)

  • abnormal limb bud morphology (MP:0005650)

  • abnormal liquid preference (MP:0001423)

  • abnormal locomotor activation (MP:0003313)

  • abnormal neocortex morphology (MP:0008547)

  • abnormal nervous system development (MP:0003861)

  • abnormal neural tube morphology (MP:0002151)

  • abnormal notochord morphology (MP:0002825)

  • abnormal pericardial cavity morphology (MP:0012501)

  • abnormal placenta development (MP:0001712)

  • abnormal primitive streak formation (MP:0002230)

  • abnormal roof plate morphology (MP:0000923)

  • abnormal social investigation (MP:0001360)

  • abnormal somite development (MP:0001688)

  • abnormal spinal cord morphology (MP:0000955)

  • abnormal vertebral body development (MP:0005227)

  • abnormal vertebral body morphology (MP:0000141)

  • abnormal vocalization (MP:0001529)

  • absent corpus callosum (MP:0002196)

  • absent hindlimb buds (MP:0013168)

  • absent notochord (MP:0000932)

  • bleb (MP:0008854)

  • caudal body truncation (MP:0004073)

  • decreased anterior commissure size (MP:0008226)

  • decreased anxiety-related response (MP:0001364)

  • decreased caudal vertebrae number (MP:0001539)

  • decreased embryo size (MP:0001698)

  • decreased hippocampal commissure size (MP:0008222)

  • decreased presacral vertebrae number (MP:0000461)

  • delayed heart development (MP:0012082)

  • distended urinary bladder (MP:0000539)

  • embryonic lethality during organogenesis, complete penetrance (MP:0011098)

  • excessive vocalization (MP:0013140)

  • hemopericardium (MP:0005244)

  • hemorrhage (MP:0001914)

  • hindlimb paralysis (MP:0000755)

  • impaired social transmission of food preference (MP:0002969)

  • increased body weight (MP:0001260)

  • increased fluid intake (MP:0011941)

  • increased grooming behavior (MP:0001441)

  • increased growth rate (MP:0002865)

  • kinked neural tube (MP:0003400)

  • limbs/digits/tail phenotype (MP:0005371)

  • low sweet preference (MP:0012347)

  • male infertility (MP:0001925)

  • notochord degeneration (MP:0004712)

  • postnatal lethality (MP:0002082)

  • reproductive system phenotype (MP:0005389)

  • sparse hair (MP:0000416)

  • spina bifida (MP:0003054)

  • split notochord (MP:0004713)

  • transmission ratio distortion (MP:0004179)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The recipient may use the BIOLOGICAL RESOURCE only for research-related, non-commercial purposes. Neither the BIOLOGICAL RESOURCE nor any biological materials treated therewith will be used in human beings. If the publication comes about, the recipient agrees to acknowledge UT AUSTIN scientists, as academically and scientifically appropriate, based on provision of the BIOLOGICAL RESOURCE or other direct contribution to the Research. The BIOLOGICAL RESOURCE will not be used in research that is subject to consulting or licensing obligations of RIKEN BRC to another individual, institution or business entity unless prior written permission is obtained from UT AUSTIN and Sloan Kettering. The recipient will use the BIOLOGICAL RESOURCE in compliance with all laws, governmental regulations and guidelines applicable to the BIOLOGICAL RESOURCE, including any such laws, governmental regulations and guidelines applicable to research with recombinant DNA, and when the BIOLOGICAL RESOURCE is used in the United States, the recipient of the BIOLOGICAL RESOURCE will comply with current NIH guidelines.
    DepositorKaren Artzt (The University of Texas at Austin)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data