Strain Data Sheet

RBRC01204

Strain Information

Image
BRC No.RBRC01204
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameSTOCK T tf +/t<E510> + Lmf1<cld>/ArtRbrc
Former Common namecld (combined lipase deficiency)
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentFrom Sloan Kettering-mice have been maintained@Univ.Tx @ Austin since 1987
Strain descriptionLarge litters : 6-10 pups
Colony maintenanceParental cage : 2 males x 3 females - always better to have two males if possible for max breeding - one becomes dominant, other subordinate three females - always one preg - efficiency (even though zero tailed)=A
References
Combined lipase deficiency (cld): a lethal mutation on chromosome 17 of the mouse.
Paterniti J R Jr, Brown W V, Ginsberg H N, Artzt K
Science, 221, 167-169 (1983). 6857276

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Itpr3
MGI:96624		inositol 1,4,5-triphosphate receptor 317Itpr3<tf>
MGI:1857070		tufted
  • type 1 diabetes mellitus(MedGEN)
    • Lmf1
    MGI:1923733    		lipase maturation factor 117Lmf1<cld>
    MGI:1856820    		combined lipase deficiency
  • lipase deficiency, combined(MedGEN)
    • T
    MGI:98472    		brachyury, T-box transcription factor T17T<T>
    MGI:1856184    		brachyury
  • neural tube defect(MedGEN)

  • sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome(MedGEN)
    • t
    MGI:105076    		t-complex17t<E510> t, E510

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal dorsal aorta morphology(MP:0004787)

  • abnormal epidermal layer morphology(MP:0001216)

  • abnormal forelimb bud morphology(MP:0013164)

  • abnormal head shape(MP:0011495)

  • abnormal heart looping(MP:0000269)
    • more 38 phenotypes
  • abnormal heart tube morphology(MP:0000270)

  • abnormal limb bud morphology(MP:0005650)

  • abnormal nervous system development(MP:0003861)

  • abnormal neural tube morphology(MP:0002151)

  • abnormal notochord morphology(MP:0002825)

  • abnormal pericardial cavity morphology(MP:0012501)

  • abnormal placenta development(MP:0001712)

  • abnormal primitive streak formation(MP:0002230)

  • abnormal somite development(MP:0001688)

  • absent hindlimb buds(MP:0013168)

  • absent notochord(MP:0000932)

  • bleb(MP:0008854)

  • caudal body truncation(MP:0004073)

  • cyanosis(MP:0001575)

  • decreased caudal vertebrae number(MP:0001539)

  • decreased embryo size(MP:0001698)

  • decreased lipoprotein lipase activity(MP:0011579)

  • decreased locomotor activity(MP:0001402)

  • decreased presacral vertebrae number(MP:0000461)

  • decreased triglyceride lipase activity(MP:0011582)

  • decreased ventral ectodermal ridge size(MP:0012714)

  • delayed heart development(MP:0012082)

  • embryonic lethality during organogenesis, complete penetrance(MP:0011098)

  • heart hemorrhage(MP:0009698)

  • hemopericardium(MP:0005244)

  • hemorrhage(MP:0001914)

  • hyperchylomicronemia(MP:0009699)

  • increased circulating cholesterol level(MP:0005178)

  • increased circulating triglyceride level(MP:0001552)

  • internal hemorrhage(MP:0001634)

  • kinked neural tube(MP:0003400)

  • liver hemorrhage(MP:0003888)

  • lung hemorrhage(MP:0001182)

  • notochord degeneration(MP:0004712)

  • pallor(MP:0003717)

  • postnatal lethality(MP:0002082)

  • short tail(MP:0000592)

  • slow postnatal weight gain(MP:0008489)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The recipient may use the BIOLOGICAL RESOURCE only for research-related, non-commercial purposes. Neither the BIOLOGICAL RESOURCE nor any biological materials treated therewith will be used in human beings. If the publication comes about, the recipient agrees to acknowledge UT AUSTIN scientists, as academically and scientifically appropriate, based on provision of the BIOLOGICAL RESOURCE or other direct contribution to the Research. The BIOLOGICAL RESOURCE will not be used in research that is subject to consulting or licensing obligations of RIKEN BRC to another individual, institution or business entity unless prior written permission is obtained from UT AUSTIN and Sloan Kettering. The recipient will use the BIOLOGICAL RESOURCE in compliance with all laws, governmental regulations and guidelines applicable to the BIOLOGICAL RESOURCE, including any such laws, governmental regulations and guidelines applicable to research with recombinant DNA, and when the BIOLOGICAL RESOURCE is used in the United States, the recipient of the BIOLOGICAL RESOURCE will comply with current NIH guidelines.
    DepositorKaren Artzt (The University of Texas at Austin)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data