Strain Data Sheet

RBRC01205

Strain Information

Image
BRC No.RBRC01205
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameSTOCK T tf/t<w12> tf
Former Common nameTtf/t<w12>tf
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentFrom Sloan Kettering-mice have been maintained @ Univ. Tx @ Austin since 1987
Strain descriptionLarge litters 6-10 pups
Colony maintenanceParental cage : 2 males x 3 females - always better to have two males if possible for max breeding - one becomes dominant, other subordinate three females - always one preg, efficiency even though zero tailed=A-B
References
Rescue of embryonic cells homozygous for a lethal haplotype of the T/t complex: tw12.
Axelrod H R, Artzt K, Bennett D
Dev. Biol., 86, 419-425 (1981). 7286406

Health Report

Examination Date / Room / Rack2024/01/22Room:3-CRack:DSentinel mouse program
2023/10/23Room:3-CRack:DSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Itpr3
MGI:96624		inositol 1,4,5-triphosphate receptor 317Itpr3<tf>
MGI:1857070		tufted
  • type 1 diabetes mellitus(MedGEN)
    • T
    MGI:98472    		brachyury, T-box transcription factor T17T
    MGI:1856184    		brachyury
  • neural tube defect(MedGEN)

  • sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome(MedGEN)
    • t
    MGI:105076    		t-complex17t<w12>
    MGI:1856568    		t, wild 12

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal allogrooming behavior (MP:0011000)

  • abnormal brain commissure morphology (MP:0002199)

  • abnormal cerebral cortex morphology (MP:0000788)

  • abnormal coat/ hair morphology (MP:0000367)

  • abnormal gustatory system physiology (MP:0001985)
    • more 19 phenotypes
  • abnormal hair cycle (MP:0000427)

  • abnormal hair growth (MP:0002073)

  • abnormal liquid preference (MP:0001423)

  • abnormal locomotor activation (MP:0003313)

  • abnormal neocortex morphology (MP:0008547)

  • abnormal social investigation (MP:0001360)

  • abnormal vocalization (MP:0001529)

  • absent corpus callosum (MP:0002196)

  • decreased anterior commissure size (MP:0008226)

  • decreased anxiety-related response (MP:0001364)

  • decreased hippocampal commissure size (MP:0008222)

  • excessive vocalization (MP:0013140)

  • impaired social transmission of food preference (MP:0002969)

  • increased body weight (MP:0001260)

  • increased fluid intake (MP:0011941)

  • increased grooming behavior (MP:0001441)

  • increased growth rate (MP:0002865)

  • low sweet preference (MP:0012347)

  • sparse hair (MP:0000416)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDevelopmental Biology Research
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The recipient may use the BIOLOGICAL RESOURCE only for research-related, non-commercial purposes. Neither the BIOLOGICAL RESOURCE nor any biological materials treated therewith will be used in human beings. If the publication comes about, the recipient agrees to acknowledge UT AUSTIN scientists, as academically and scientifically appropriate, based on provision of the BIOLOGICAL RESOURCE or other direct contribution to the Research. The BIOLOGICAL RESOURCE will not be used in research that is subject to consulting or licensing obligations of RIKEN BRC to another individual, institution or business entity unless prior written permission is obtained from UT AUSTIN and Sloan Kettering. The recipient will use the BIOLOGICAL RESOURCE in compliance with all laws, governmental regulations and guidelines applicable to the BIOLOGICAL RESOURCE, including any such laws, governmental regulations and guidelines applicable to research with recombinant DNA, and when the BIOLOGICAL RESOURCE is used in the United States, the recipient of the BIOLOGICAL RESOURCE will comply with current NIH guidelines.
    DepositorKaren Artzt (The University of Texas at Austin)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data