Strain Data Sheet

RBRC01206

Strain Information

Image
BRC No.RBRC01206
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameBTBRTF/ArtRbrc
Former Common nameBT nt tf=Tufted
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentFrom Sloan Kettering-mice have been maintained @ Univ. Tx @ Austin since 1987
Strain descriptionLarge, Large litters - 9 pups plus - but slow to begin breeding.
Colony maintenanceParental cage : 2 males x 3 females - always better to have two males if possible for max. breeding - one becomes dominant, other subordinate, three females - always one preg - efficiency B-C - slow to reproduce.
References

Health Report

Examination Date / Room / Rack2024/11/25Room:4-CRack:ESentinel mouse program
2024/08/26Room:4-CRack:ESentinel mouse program
2024/05/27Room:4-CRack:ESentinel mouse program
2024/02/26Room:4-CRack:ESentinel mouse program
2023/11/27Room:4-CRack:ESentinel mouse program
2023/08/28Room:4-CRack:ESentinel mouse program
2023/05/29Room:4-CRack:ESentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Itpr3
MGI:96624		inositol 1,4,5-triphosphate receptor 317Itpr3<tf>
MGI:1857070		tufted
  • type 1 diabetes mellitus(MedGEN)
    • T
    MGI:98472    		brachyury, T-box transcription factor T17T
    MGI:1856184    		brachyury
  • neural tube defect(MedGEN)

  • sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome(MedGEN)
    • a
    MGI:87853    		nonagouti2a<t>
    MGI:1855941    		black and tan

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal allogrooming behavior(MP:0011000)

  • abnormal brain commissure morphology(MP:0002199)

  • abnormal cerebral cortex morphology(MP:0000788)

  • abnormal coat/ hair morphology(MP:0000367)

  • abnormal coat/hair pigmentation(MP:0002075)
    • more 68 phenotypes
  • abnormal dorsal aorta morphology(MP:0004787)

  • abnormal dorsoventral coat patterning(MP:0008238)

  • abnormal epidermal layer morphology(MP:0001216)

  • abnormal forelimb bud morphology(MP:0013164)

  • abnormal gustatory system physiology(MP:0001985)

  • abnormal hair cycle(MP:0000427)

  • abnormal hair growth(MP:0002073)

  • abnormal head shape(MP:0011495)

  • abnormal heart looping(MP:0000269)

  • abnormal heart tube morphology(MP:0000270)

  • abnormal limb bud morphology(MP:0005650)

  • abnormal liquid preference(MP:0001423)

  • abnormal locomotor activation(MP:0003313)

  • abnormal lumbar vertebrae morphology(MP:0003049)

  • abnormal neocortex morphology(MP:0008547)

  • abnormal nervous system development(MP:0003861)

  • abnormal neural tube morphology(MP:0002151)

  • abnormal pericardial cavity morphology(MP:0012501)

  • abnormal placenta development(MP:0001712)

  • abnormal primitive streak formation(MP:0002230)

  • abnormal rostral-caudal body axis extension(MP:0003885)

  • abnormal social investigation(MP:0001360)

  • abnormal somite development(MP:0001688)

  • abnormal tail bud morphology(MP:0002861)

  • abnormal tail development(MP:0006281)

  • abnormal tail morphology(MP:0002111)

  • abnormal thoracic vertebrae morphology(MP:0003047)

  • abnormal ventral coat pigmentation(MP:0008237)

  • abnormal vocalization(MP:0001529)

  • absent caudal vertebrae(MP:0004653)

  • absent corpus callosum(MP:0002196)

  • absent hindlimb buds(MP:0013168)

  • absent notochord(MP:0000932)

  • absent tail(MP:0003456)

  • absent vertebrae(MP:0000138)

  • absent vertebral arch(MP:0004603)

  • absent vertebral body(MP:0004668)

  • bleb(MP:0008854)

  • caudal body truncation(MP:0004073)

  • darkened coat color(MP:0005409)

  • decreased anterior commissure size(MP:0008226)

  • decreased anxiety-related response(MP:0001364)

  • decreased caudal vertebrae number(MP:0001539)

  • decreased embryo size(MP:0001698)

  • decreased hippocampal commissure size(MP:0008222)

  • decreased presacral vertebrae number(MP:0000461)

  • decreased survivor rate(MP:0008770)

  • decreased ventral ectodermal ridge size(MP:0012714)

  • delayed heart development(MP:0012082)

  • embryonic lethality during organogenesis, complete penetrance(MP:0011098)

  • excessive vocalization(MP:0013140)

  • hemopericardium(MP:0005244)

  • hemorrhage(MP:0001914)

  • impaired social transmission of food preference(MP:0002969)

  • increased body weight(MP:0001260)

  • increased fluid intake(MP:0011941)

  • increased grooming behavior(MP:0001441)

  • increased growth rate(MP:0002865)

  • irregular coat pigmentation(MP:0000372)

  • kinked neural tube(MP:0003400)

  • low sweet preference(MP:0012347)

  • meningomyelocele(MP:0009929)

  • notochord degeneration(MP:0004712)

  • perinatal lethality, incomplete penetrance(MP:0011090)

  • short tail(MP:0000592)

  • sparse hair(MP:0000416)

  • split notochord(MP:0004713)

  • transmission ratio distortion(MP:0004179)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The recipient may use the BIOLOGICAL RESOURCE only for research-related, non-commercial purposes. Neither the BIOLOGICAL RESOURCE nor any biological materials treated therewith will be used in human beings. If the publication comes about, the recipient agrees to acknowledge UT AUSTIN scientists, as academically and scientifically appropriate, based on provision of the BIOLOGICAL RESOURCE or other direct contribution to the Research. The BIOLOGICAL RESOURCE will not be used in research that is subject to consulting or licensing obligations of RIKEN BRC to another individual, institution or business entity unless prior written permission is obtained from UT AUSTIN and Sloan Kettering. The recipient will use the BIOLOGICAL RESOURCE in compliance with all laws, governmental regulations and guidelines applicable to the BIOLOGICAL RESOURCE, including any such laws, governmental regulations and guidelines applicable to research with recombinant DNA, and when the BIOLOGICAL RESOURCE is used in the United States, the recipient of the BIOLOGICAL RESOURCE will comply with current NIH guidelines.
    DepositorKaren Artzt (The University of Texas at Austin)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    Strain AvailabilityCryopreserved embryos (within 1 month)
    Live mouse (1 to 3 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Mizuno S, Hirota JN, Ishii C, Iwasaki H, Sano Y, Furuichi T.
    Comprehensive Profiling of Gene Expression in the Cerebral Cortex and Striatum of BTBRTF/ArtRbrc Mice Compared to C57BL/6J Mice.
    Front Cell Neurosci 14 595607(2020) 33362469