Strain Data Sheet

RBRC01221

Strain Information

Image
BRC No.RBRC01221
TypeInbred
SpeciesMus musculus
Strain nameSM/J
Former Common name
H-2 Haplotype
ES Cell line
Background strainSM
Appearanceblack [a/a]
white-bellied agouti [A<w>/a]
Strain developmentDeveloped by MacArthur in 1939. The SM/J strain was produced by crossing seven inbred strains including DBA and selecting for small body size. This strain was introduced to National Institute of Genetics from the Jackson laboratory in 1985, subsequently maintained by Dr. Masahiko Nishimura at Hamamatsu University School of Medicine, and then Nagoya University.
Strain descriptionThe SM/J strain is segregating inbred strain for the agouti alleles white-bellied agouti (A<w>) and black (a). Developed by MacArthur in 1939. These mice are susceptible to diet-induced atherosclerosis and obesity without diabetes. The body size is small at birth and weaning, but attain a normal body weight as the animals mature.
Colony maintenanceSibling mating (white-bellied agouti x black)
References
Genetic analysis of mortality in murine angiostrongyliasis costaricensis using SMXA recombinant inbred mouse strains.
Ishih A, Ohno T, Nishimura M, Terada M
Parasitol Int, 49(4):335-338 (2000). 11077268

Characterization of hyperinsulinemic recombinant inbred (RI) strains (SMXA-5 and SMXA-9) derived from normoinsulinemic SM/J and A/J mice.
Anunciado R V, Horio F, Ohno T, Tanaka S, Nishimura M, Namikawa T
Exp Anim, 49(2):83-90 (2000). 10889946

Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis.
Anunciado R V, Ohno T, Mori M, Ishikawa A, Tanaka S, Horio F, Nishimura M, Namikawa T
Exp Anim, 49(3):217-224 (2000). 11109545

Quantitative trait loci for body weight in the intercross between SM/J and A/J mice.
Anunciado R V, Nishimura M, Mori M, Ishikawa A, Tanaka S, Horio F, Ohno T, Namikawa T
Exp Anim, 50(4):319-324 (2001). 11515095

Chromosomal mapping of host susceptibility loci to Angiostrongylus costaricensis nematode infection in mice.
Ohno T, Ishih A, Tanaka S, Nishimura M, Terada M
Immunogenetics, 53(10-11):925-929 (2002). 11862393

Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J x A/J)F2 mice.
Anunciado R V, Nishimura M, Mori M, Ishikawa A, Tanaka S, Horio F, Ohno T, Namikawa T
Exp Anim, 52(5):415-417 (2003). 12638235

Combinations of nondiabetic parental genomes elicit impaired glucose tolerance in mouse SMXA recombinant inbred strains.
Kobayashi M, Ohno T, Tsuji A, Nishimura M, Horio F
Diabetes, 52(1):180-186 (2003). 12502510

Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J x A/J)F2 mice.
Anunciado R V, Nishimura M, Mori M, Ishikawa A, Tanaka S, Horio F, Ohno T, Namikawa T
Exp Anim, 52(1):37-42 (2003). 12638235

SMXA-5 mouse as a diabetic model susceptible to feeding a high-fat diet.
Kobayashi M, Io F, Kawai T, Nishimura M, Ohno T, Horio F
Biosci Biotechnol Biochem, 68(1):226-230 (2004). 14745189

Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains.
Kobayashi M, Io F, Kawai T, Kumazawa M, Ikegami H, Nishimura M, Ohno T, Horio F
Diabetologia, 49(3):486-495 (2006). 16447060
more 8 references
Serum adiponectin concentration: its correlation with diabetes-related traits and quantitative trait loci analysis in mouse SMXA recombinant inbred strains.
Kobayashi M, Ohno T, Kawada T, Ikegami H, Nishimura M, Horio F
Biosci Biotechnol Biochem, 70(3): 677-683 (2006). 16556985

Searching for genetic factors of fatty liver in SMXA-5 mice by quantitative trait loci analysis under a high-fat diet.
Kumazawa M, Kobayashi M, Io F, Kawai T, Nishimura M, Ohno T, Horio F
J Lipid Res, 48(9): 2039-2046 (2007). 17595448

Quantitative trait loci for impaired glucose tolerance in nondiabetic SM/J and A/J mice.
Hada N, Kobayashi M, Fujiyoshi M, Ishikawa A, Kuga M, Nishimura M, Ebihara S, Ohno T, Horio F
Physiol Genomics, 35(1): 65-74 (2008). 18628340

Confirmation of diabetes-related quantitative trait loci derived from SM/J and A/J mice by using congenic strains fed a high-carbohydrate or high-fat diet.
Kobayashi M, Hada N, Hoshino H, Ozawa T, Umeshita K, Nishimura M, Murai A, Ohno T, Horio F
J Nutr Sci Vitaminol, 55(3): 257-263 (2009). 19602834

Body and major organ weights of A/J-Chr 11(SM) consomic mice.
Tanaka S, Mizorogi T, Nishijima K, Kuwahara S, Tsujio M, Aoyama H, Taguchi C, Kobayashi M, Horio F, Ohno T
Exp Anim, 58(4): 357-361 (2009). 19654433

Genetic analysis of abdominal fat distribution in SM/J and A/J mice.
Kobayashi M, Ohno T, Hada N, Fujiyoshi M, Kuga M, Nishimura M, Murai A, Horio F
J Lipid Res, 51(12): 3463-3469 (2010). 20802160

Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits.
Ohno T, Hata K, Baba T, Io F, Kobayashi M, Horio F, Nishimura M
Mamm Genome, 23(11-12):764-769 (2012). 23052825

Detection of loci for allergic asthma using SMXA recombinant inbred strains of mice.
Ohno T, Okamoto M, Hara T, Hashimoto N, Imaizumi K, Matsushima M, Nishimura M, Shimokata K, Hasegawa Y, Kawabe T
Immunogenetics, 65(1):17-24 (2013). 23081743

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationGenetics Research
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorMasahiko Nishimura (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    Kijimoto-Ochiai S, Matsumoto-Mizuno T, Kamimura D, Murakami M, Kobayashi M, Matsuoka I, Ochiai H, Ishida H, Kiso M, Kamimura K, Koda T.
    Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5.
    Glycobiology 28(5) 306-317(2018) 29897583
    Kasahara T, Abe K, Mekada K, Yoshiki A, Kato T.
    Genetic variation of melatonin productivity in laboratory mice under domestication.
    Proc Natl Acad Sci U S A 107(14) 6412-7(2010) 20308563
    Kijimoto-Ochiai S, Koda T, Suwama T, Matsukawa H, Fujii M, Tomobe K, Nishimura M.
    Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells "Neu-medullocyte" in the murine thymus.
    Glycoconj J 25(8) 787-96(2008) 18553168
    Kumazawa M, Kobayashi M, Io F, Kawai T, Nishimura M, Ohno T, Horio F.
    Searching for genetic factors of fatty liver in SMXA-5 mice by quantitative trait loci analysis under a high-fat diet.
    J Lipid Res 48(9) 2039-46(2007) 17595448
    Kobayashi M, Ohno T, Kawada T, Ikegami H, Nishimura M, Horio F.
    Serum adiponectin concentration: its correlation with diabetes-related traits and quantitative trait loci analysis in mouse SMXA recombinant inbred strains.
    Biosci Biotechnol Biochem 70(3) 677-83(2006) 16556985
    Kobayashi M, Io F, Kawai T, Kumazawa M, Ikegami H, Nishimura M, Ohno T, Horio F.
    Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains.
    Diabetologia 49(3) 486-95(2006) 16447060