Strain Data Sheet

RBRC01235

Strain Information

Image
BRC No.RBRC01235
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameSTOCK Ptpro<tm1Shs>/Rbrc
Former Common nameGlepp1-KO, Glepp1 Knockout mice
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack (a/a B/B C/C)
Strain developmentDeveloped by Dr. Takuya Tomemori at Tokyo Metropolitan Institute of Gerontology in 2001.
Strain descriptionThe Glepp1 (Ptpro) gene is a receptor tyrosine phsophatase that is present on the surface of the glomerular podocyte and plays in regulating podocyte structure and function. Homozygous mutant mice are viable and fertile.
Colony maintenanceSibling Mating (Homozygote x Homozygote)
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ptpro
MGI:1097152		protein tyrosine phosphatase receptor type O6Ptpro<tm1Shs>
MGI:5494167		targeted mutation 1, Takuji Shirasawa
  • nephrotic syndrome, type 6(MedGEN)
    • loxP phage P1 loxP6loxP
    loxP phage P1 loxP6loxP
    neo neomycin resistance gene (E. coli)6 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Glepp1 genomic DNA[update Oct., 20, 2014]
    Research applicationCell Biology Research
    Cre/loxP system
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
    DepositorTakuji Shirasawa (Tokyo Metropolitan Institute of Gerontology)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese), Lab HP (English)
    Genotyping protocol -PCR-

    BRC mice in Publications

    Shintani T, Suzuki R, Takeuchi Y, Shirasawa T, Noda M.
    Deletion or inhibition of PTPRO prevents ectopic fat accumulation and induces healthy obesity with markedly reduced systemic inflammation.
    Life Sci 313 121292(2023) 36535401
    Yu, Yang.
    Regulation of retinal axonal projections by the R3 receptor-like protein tyrosine phosphatase subfamily in mice.
    SOKENDAI (The Graduate University for Advanced Studies) (2018)