Strain Information | |
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Image | |
BRC No. | RBRC01236 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | STOCK Ahr<tm1Yfk> Nfe2l2<tm1Mym> |
Former Common name | Nrf2(+/-)::AhR(+/-) compound mouse |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | |
Strain description | |
Colony maintenance | |
References | An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, Oyake T, Hayashi N, Satoh K, Hatayama I, Yamamoto M, Nabeshima Y Biochem. Biophys. Res. Commun., 236, 313-322 (1997). 9240432Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Mimura J, Yamashita K, Nakamura K, Morita M, Takagi T N, Nakao K, Ema M, Sogawa K, Yasuda M, Katsuki M, Fujii-Kuriyama Y Genes Cells, 2, 645-654 (1997). 9427285Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse. Noda S, Harada N, Hida A, Fujii-Kuriyama Y, Motohashi H, Yamamoto M Biochem. Biophys. Res. Commun., 303, 105-111 (2003). 12646173 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Ahr MGI:105043 | aryl-hydrocarbon receptor | 12 | Ahr<tm1Yfk> | targeted mutation 1, Yoshiaki Fujii-Kuriyama | |||
lacZ | beta-galactosidase (E. coli) | 12 | |||||
neo | neomycin resistance gene (E. coli) | 12 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) | ||||
nls | SV40 large T antigen nuclear localization signal (NLS) | 12 | nls | ||||
Nfe2l2 MGI:108420 | nuclear factor, erythroid derived 2, like 2 | 2 | Nfe2l2<tm1Mym> MGI:2385925 | targeted mutation 1, Masayuki Yamamoto | |||
lacZ | beta-galactosidase (E. coli) | 2 | |||||
neo | neomycin resistance gene (E. coli) | 2 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) | ||||
nls | SV40 large T antigen nuclear localization signal (NLS) | 2 | nls |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 63 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | Simian virus 40 Large T antigen nuclear localization signal (NLS), E. coli lacZ, herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Nrf2 genomic DNA, mouse Ahr genomic DNA, SV40 T antigen intron and polyadenylation signal |
Research application | Cell Biology Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Noda S.et al. (2003) BIochem Biophys Res Commun. 303:105-111.In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC. The RECIPIENT should contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Masayuki Yamamoto (University of Tsukuba) |
Strain Status | ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
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BRC mice in Publications |
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