Strain Data Sheet

RBRC01309

Strain Information

Image
BRC No.RBRC01309
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(GMB7)1Rin/RinRbrc
Former Common nameAnti-ganglioside GD2 antibody transgenic mouse
H-2 Haplotype
ES Cell line
Background strainC57BL/6J
Appearance
Strain development
Strain description
Colony maintenance
References
Expansion of natural killer cells in mice transgenic for IgM antibody to ganglioside GD2: demonstration of prolonged survival after challenge with syngeneic tumor cells.
Kawashima I, Yoshida Y, Taya C, Shitara H, Yonekawa H, Karasuyama H, Tada N, Furukawa K, Tai T
Int. J. Oncol., 23 381-388 (2003). 12851687

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GMB7 UNGMB7 transgene insertion 1, The Tokyo Metropolitan Institute of Medical Science

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • decreased tumor incidence(MP:0002052)

  • increased NK cell number(MP:0008044)

  • increased natural killer cell mediated cytotoxicity(MP:0003080)
    • Detailed phenotype data

    Ordering Information

    Donor DNA抗糖鎖抗体(GMB7: b-pathway gangliosides認識)の可変領域遺伝子をIgM重鎖カセット(V167 μ)とIgM軽鎖カセット(pMM222)に導入したもの
    Research applicationCancer Research
    Cell Biology Research
    Immunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Int. J. Oncol., 23, 381-388 (2003).
    DepositorTadashi Tai (Tokyo Metropolitan Institute of Medical Science)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data