Strain Data Sheet

RBRC01312

Strain Information

Image
BRC No.RBRC01312
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S4(Cg)-Ogg1<tm1.1Tno>
Former Common nameMmh/Ogg1 Knockout Mouse
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strain
Appearance
Strain developmentDeveloped by Osamu Minowa, Masanori Hirano and Testuo Noda, The Cancer Institute, Japanese Foundation for Cancer Research in 1997-2000. A pgk-neo (Ogg1<tm1Tno> allele ) was removed in Ogg1<tm1.1Tno> allele.
Strain description
Colony maintenance
References
Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice.
Minowa O, Arai T, Hirano M, Monden Y, Nakai S, Fukuda M, Itoh M, Takano H, Hippou Y, Aburatani H, Masumura K, Nohmi T, Nishimura S, Noda T
Proc. Natl. Acad. Sci. USA, 97, 4156-4161 (2000). 10725358

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ogg1
MGI:1097693		8-oxoguanine DNA-glycosylase 16Ogg1<tm1Tno> targeted mutation 1, Tetsuo Noda
  • nonpapillary renal cell carcinoma(MedGEN)
    • loxP phage P1 loxP6loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal DNA repair(MP:0008058)

  • liver/biliary system phenotype(MP:0005370)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP, mouse Mmh/Ogg1 genomic DNA
    Research applicationCancer Research
    Cre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 97, 4156-4161 (2000). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorTetsuo Noda (Japanese Foundation For Cancer Research)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data