Strain Information | |
---|---|
Image | |
BRC No. | RBRC01342 |
Type | Transgene |
Species | Mus musculus |
Strain name | C57BL/6J-Tg(Emx1-cre)1Ito/ItoRbrc |
Former Common name | Emx1-Cre Tg1 |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Takuji Iwasato and Shigeyoshi Itohara, RIKEN Brain Science Institute. The transgene was injected into the pronuclei of C57BL/6 fertilized eggs. C57BL/6 background. |
Strain description | Emx1-Cre transgenitc mice, containing a transcriptional unit of a dorsal telencephalon specific promoter (Emx1 promoter) and Cre recombinase gene. Line 1 (RBRC01342), Line 2 (RBRC01343) and Line 3 (RBRC01344). The most suitable cre driver strain is Emx1-cre delta neo knock-in mice (RBRC01345) (no ectopic cre expression is detected). |
Colony maintenance | Carrier x Noncarrier [C57BL/6JJcl] |
References | Genesis, 38, 130-138 (2004). 15048810 |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |
---|---|
Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter crePhage P1 Cre recombinaseUNcremouse Emx1 (Drosophila homeobox gene empty spiracles (Ems) mouse homolog) promoter, SV40 poly A Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter nlsSV40 large T antigen nuclear localization signal (NLS)UNnls |
Ordering Information | |
---|---|
Donor DNA | mouse Emx1 (Drosophila homeobox gene empty spiracles (Ems) mouse homolog) promoter, Simian virus 40 Large T antigen nuclear localization signal (NLS), phage P1 Cre recombinase, SV40 poly A |
Research application | Cre/loxP system |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genesis, 38, 130-138 (2004). |
Depositor | Shigeyoshi Itohara (RIKEN) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month June 2006 |
BRC mice in Publications |
---|
Pearson CA, Moore DM, Tucker HO, Dekker JD, Hu H, Miquelajáuregui A, Novitch BG. Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates. Cell Rep 30(6) 1964-1981.e3(2020) 32049024 Chen CM, Wang HY, You LR, Shang RL, Liu FC. Expression analysis of an evolutionarily conserved metallophosphodiesterase gene, Mpped1, in the normal and beta-catenin-deficient malformed dorsal telencephalon. Dev Dyn 239(6) 1797-806(2010) 20503375 Buth JE, Dyevich CE, Rubin A, Wang C, Gao L, Marks T, Harrison MR, Kong JH, Ross ME, Novitch BG, Pearson CA. Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha signaling to promote neural progenitor cell maintenance. EMBO Rep (2024) 38600346 |