Strain Data Sheet

RBRC01350

Strain Information

Image
BRC No.RBRC01350
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Plcl1<tm1Mh>/MhRbrc
Former Common nameC57BL/6 PRIP-1-/- (PRIP-1 KO, p130 KO)
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function.
Kanematsu T, Jang I S, Yamaguchi T, Nagahama H, Yoshimura K, Hidaka K, Matsuda M, Takeuchi H, Misumi Y, Nakayama K, Yamamoto T, Akaike N, Hirata M, Nakayama K
EMBO J., 21, 1004-1011 (2002). 11867528

GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein.
Terunuma M, Jang I S, Ha S H, Kittler J T, Kanematsu T, Jovanovic J N, Nakayama K I, Akaike N, Ryu S H, Moss S J, Hirata M
J. Neurosci., 24, 7074-7084 (2004). 15306641

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Plcl1
MGI:3036262		phospholipase C-like 11Plcl1<tm1Mh>
MGI:3526123		targeted mutation 1, Masato Hirata
neo neomycin resistance gene (E. coli)1 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal motor coordination/balance(MP:0001516)

  • abnormal nervous system electrophysiology(MP:0002272)

  • impaired behavioral response to xenobiotic(MP:0009747)

  • increased susceptibility to pharmacologically induced seizures(MP:0002906)

  • increased susceptibility to xenobiotic induced morbidity/mortality(MP:0009766)
    • more 1 phenotypes
  • seizures(MP:0002064)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse p130 genomic DNA
    Research applicationCell Biology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO J., 21, 1004-1011 (2002). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT should contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
    The RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a con-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC.
    DepositorMasato Hirata (Kyushu University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data