Strain Data Sheet

RBRC01359

Strain Information

Image
BRC No.RBRC01359
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(Grm2-IL2RA/EGFP)16Kyo
Former Common nameMG-IG16
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination.
Watanabe D, Inokawa H, Hashimoto K, Suzuki N, Kano M, Shigemoto R, Hirano T, Toyama K, Kaneko S, Yokoi M, Moriyoshi K, Suzuki M, Kobayashi K, Nagatsu T, Kreitman R J, Pastan I, Nakanishi S
Cell, 95, 17-27 (1998). 9778244

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GFP Green Fluorescent Protein (Aequorea victoria)UN
IL2RA Interleukin-2 receptor α-subunit (human)UNIL2RA mouse mGluR2 promoter

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal autopod morphology(MP:0000572)

  • abnormal cerebellar Golgi cell morphology(MP:0009512)

  • abnormal motor coordination/balance(MP:0001516)

  • abnormal nervous system electrophysiology(MP:0002272)

  • athetotic walking movements(MP:0001527)
    • more 1 phenotypes
  • impaired balance(MP:0001525)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse mGluR2 promoter, human IL-2R alpha cDNA, jellyfish GFP cDNA, polyA
    Research applicationFluorescent Proteins/lacZ System
    General Purpose
    Neurobiology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell, 95, 17-27 (1998).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorShigetada Nakanishi (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data