Strain Data Sheet

RBRC01360

Strain Information

Image
BRC No.RBRC01360
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Grm5<tm1(T840D)Kyo>
Former Common namemGluR5 T840D
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strainC57BL/6JJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors.
Kawabata S, Tsutsumi R, Kohara A, Yamaguchi T, Nakanishi S, Okada M
Nature, 383, 89-92 (1996). 8779726

Altered agonist sensitivity and desensitization of neuronal mGluR1 responses in knock-in mice by a single amino acid substitution at the PKC phosphorylation site.
Sato M, Tabata T, Hashimoto K, Nakamura K, Nakao K, Katsuki M, Kitano J, Moriyoshi K, Kano M, Nakanishi S
Eur. J. Neurosci., 20, 947-955 (2004). 15305863

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Grm5
MGI:1351342		glutamate receptor, metabotropic 57Grm5<tm1(T840D)Kyo> targeted mutation 1 (T840D), Shigetada Nakanishi
loxP phage P1 loxP7loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • normal phenotype(MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse glutamate receptor(mGluR) 5 genomic DNA, poly A, mouse glutamate receptor(mGluR) 5 T840D genomic DNA, Phage P1 loxP
    Research applicationNeurobiology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 383, 89-92 (1996). Eur J. Neurosci., 20, 947-955 (2004).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorShigetada Nakanishi (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data