Strain Data Sheet

RBRC01377

Strain Information

Image
BRC No.RBRC01377
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameICR.Cg-Meox1<tm1(cre)Ysa>/YsaRbrc
Former Common nameMox1-cre
H-2 Haplotype
ES Cell line
Background strainICR
Appearancealbino [c/c]
Strain developmentDeveloped by Dr. Yumiko Saga (2004). This strain were maintained under ICR background.
Strain descriptionICR.Cg-Meox1<tm>. The Meox1 gene is a homeobox family gene, require for meterminig anterioposterior regionalization of mesoderm and in somite differentiation. In this mutant mouse, A cre recombinase gene was inserted in Mox1 gene.
Colony maintenanceHomozygtote x Heterozygote or Crossing to ICR (Jcl:MCH)
References
Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2.
Nakajima Y, Morimoto M, Takahashi Y, Koseki H, Saga Y
Development, 133(13): 2517-2525 (2006). 16728472

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Meox1
MGI:103220		mesenchyme homeobox 111Meox1<tm1(cre)Ysa> targeted mutation 1, Yumiko Saga
  • Klippel-Feil syndrome 2, autosomal recessive(MedGEN)
    • cre Phage P1 Cre recombinase11cre
    loxP phage P1 loxP11loxP
    loxP phage P1 loxP11loxP
    neo neomycin resistance gene (E. coli)11 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 Cre recombinase, poly A, Phage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, bovine GH poly A, mouse Mox1 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Development, 133, 2517-2525 (2006).
    DepositorYumiko Saga (National Institute of Genetics)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Saga Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data