Strain Data Sheet

RBRC01420

Strain Information

Image
BRC No.RBRC01420
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Irf7<tm1Ttg>/TtgRbrc
Former Common nameIRF-7-KO, IRF7, IRF-7 knockout mice, C57BL/6J
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strainC57BL/6J
Appearanceblack [a/a]
Strain developmentDeveloped by Kenya Honda and Tadatsugu Taniguchi, Graduate School of Medicine and Faculty of Medicine, University of Tokyo in 2001. The knockout construct was electroporated into E14 ES cells derived from 129P2/OlaHsd. C57BL/6 semicongenic strain.
Strain descriptionIRF7 knockout mice. Exon 2 and 3 of Irf7 gene were replaced with a PGK-beta-geo cassette. Homozygous mutant mice are vulnerable to viral infection with a decreased serum interferon level.
Colony maintenanceHomozygote x Homozygote
References
IRF-7 is the master regulator of type-I interferon-dependent immune responses.
Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T
Nature, 434, 772-777 (2005). 15800576

Health Report

Examination Date / Room / Rack2024/11/25Room:4-BRack:LSentinel mouse program
2024/08/26Room:4-BRack:LSentinel mouse program
2024/05/27Room:4-BRack:LSentinel mouse program
2024/02/26Room:4-BRack:LSentinel mouse program
2023/11/27Room:4-BRack:LSentinel mouse program
2023/09/28Room:4-BRack:LAdditional tests
2023/08/28Room:4-BRack:LSentinel mouse program
2023/05/29Room:4-BRack:LSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Irf7
MGI:1859212		interferon regulatory factor 77Irf7<tm1Ttg>
MGI:3577089		targeted mutation 1, Tadatsugu Taniguchi
  • immunodeficiency 39(MedGEN)
    • lacZ beta-galactosidase (E. coli)7 mouse phosphoglycerate kinase promoter (PGK promoter)
    neo neomycin resistance gene (E. coli)7

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal T cell physiology(MP:0002444)

  • abnormal interferon level(MP:0008750)

  • increased susceptibility to viral infection induced morbidity/mortality(MP:0009791)

  • increased susceptibility to viral infection(MP:0002418)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli beta-geo gene (E. coli neo, E. coli lacZ), mouse IRF-7 genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
    DepositorTadatsugu Taniguchi (The University of Tokyo)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Live mouse (1 to 3 months)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-
    Mouse of the Month May 2005

    BRC mice in Publications

    Sepahpour T, Alshaweesh J, Azodi N, Singh K, Ireland DDC, Valanezhad F, Nakamura R, Satoskar AR, Dey R, Hamano S, Nakhasi HL, Gannavaram S.
    Downregulation of IRF7-mediated type-I interferon response by LmCen-/- parasites is necessary for protective immunity.
    NPJ Vaccines 9(1) 250(2024) 39702382
    Yalong Yang, Vishnu Kumar, Wei Peng, Monika Fijak, Michel Gabriela, Wei Cai, Andreas Meinhardt, Sudhanshu Bhushan
    Role of Macrophage Colony Stimulating Factor and Interferon Regulatory Factor 7 in Modulating the Immune Profile of Mouse Testicular Macrophages
    Journal of Reproductive Immunology 104169(2023)
    Zhang Z, Mai Q, Yang L, Chen Y, Chen Z, Lin T, Tan S, Wu Z, Cai Y, Cui T, Ouyang B, Yang Y, Zeng L, Ge Z, Zhang S, Zeng G, Pi J, Chen L.
    MicroRNA-31 mediated by interferon regulatory factor 7 signaling facilitates control of Mycobacterium tuberculosis infection.
    Int J Med Microbiol 312(7) 151569(2022) 36274382
    Sin WX, Yeong JP, Lim TJF, Su IH, Connolly JE, Chin KC.
    IRF-7 Mediates Type I IFN Responses in Endotoxin-Challenged Mice.
    Front Immunol 11 640(2020) 32373120
    Kuroda M, Nishiguchi M, Ugawa N, Ishikawa E, Kawabata Y, Okamoto S, Sasaki W, Miyatake Y, Sebe M, Masumoto S, Tsutsumi R, Harada N, Sakaue H.
    Interferon regulatory factor 7 mediates obesity-associated MCP-1 transcription.
    PLoS One 15(5) e0233390(2020) 32437400
    Elsaesser HJ, Mohtashami M, Osokine I, Snell LM, Cunningham CR, Boukhaled GM, McGavern DB, Zúñiga-Pflücker JC, Brooks DG.
    Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection.
    Proc Natl Acad Sci U S A 117(10) 5420-5429(2020) 32094187
    Puthia M, Ambite I, Cafaro C, Butler D, Huang Y, Lutay N, Rydström G, Gullstrand B, Swaminathan B, Nadeem A, Nilsson B, Svanborg C.
    IRF7 inhibition prevents destructive innate immunity-A target for nonantibiotic therapy of bacterial infections.
    Sci Transl Med 8(336) 336ra59(2016) 27122612
    Temizoz B, Kuroda E, Ohata K, Jounai N, Ozasa K, Kobiyama K, Aoshi T, Ishii KJ.
    TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN.
    Eur J Immunol 45(4) 1159-69(2015) 25529558
    Li W, Hofer MJ, Jung SR, Lim SL, Campbell IL.
    IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus.
    J Virol 88(13) 7578-88(2014) 24760883
    Wang XA, Zhang R, Zhang S, Deng S, Jiang D, Zhong J, Yang L, Wang T, Hong S, Guo S, She ZG, Zhang XD, Li H.
    Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance.
    Am J Physiol Endocrinol Metab 305(4) E485-95(2013) 23695216
    Li W, Hofer MJ, Noçon AL, Manders P, Campbell IL.
    Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice.
    Virology 439(2) 152-62(2013) 23490048
    Zhou S, Cerny AM, Fitzgerald KA, Kurt-Jones EA, Finberg RW.
    Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection.
    J Virol 86(20) 11254-65(2012) 22875973
    Christensen JE, Fenger C, Issazadeh-Navikas S, Krug A, Liljestrøm P, Goriely S, Paludan SR, Finsen B, Christensen JP, Thomsen AR.
    Differential impact of interferon regulatory factor 7 in initiation of the type I interferon response in the lymphocytic choriomeningitis virus-infected central nervous system versus the periphery.
    J Virol 86(13) 7384-92(2012) 22514347
    Beattie L, Phillips R, Brown N, Owens BM, Chauhan N, Dalton JE, Kaye PM.
    Interferon regulatory factor 7 contributes to the control of Leishmania donovani in the mouse liver.
    Infect Immun 79(3) 1057-66(2011) 21149596
    Prantner D, Sikes JD, Hennings L, Savenka AV, Basnakian AG, Nagarajan UM.
    Interferon regulatory transcription factor 3 protects mice from uterine horn pathology during Chlamydia muridarum genital infection.
    Infect Immun 79(10) 3922-33(2011) 21788382
    Salem M, Mony JT, Løbner M, Khorooshi R, Owens T.
    Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice.
    J Neuroinflammation 8 181(2011) 22196084
    Marichal T, Bedoret D, Mesnil C, Pichavant M, Goriely S, Trottein F, Cataldo D, Goldman M, Lekeux P, Bureau F, Desmet CJ.
    Interferon response factor 3 is essential for house dust mite-induced airway allergy.
    J Allergy Clin Immunol 126(4) 836-844.e13(2010) 20673978
    Khorooshi R, Owens T.
    Injury-induced type I IFN signaling regulates inflammatory responses in the central nervous system.
    J Immunol 185(2) 1258-64(2010) 20562259
    Prantner D, Darville T, Nagarajan UM.
    Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection.
    J Immunol 184(5) 2551-60(2010) 20107183
    Molle C, Goldman M, Goriely S.
    Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process.
    J Immunol 184(4) 1784-92(2010) 20083668
    Zhou S, Cerny AM, Zacharia A, Fitzgerald KA, Kurt-Jones EA, Finberg RW.
    Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus.
    J Virol 84(18) 9452-62(2010) 20592086
    Phillips R, Svensson M, Aziz N, Maroof A, Brown N, Beattie L, Signoret N, Kaye PM.
    Innate killing of Leishmania donovani by macrophages of the splenic marginal zone requires IRF-7.
    PLoS Pathog 6(3) e1000813(2010) 20300600
    Giordano G, van den Brûle S, Lo Re S, Triqueneaux P, Uwambayinema F, Yakoub Y, Couillin I, Ryffel B, Michiels T, Renauld JC, Lison D, Huaux F.
    Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis.
    Toxicol Sci 116(2) 682-92(2010) 20513754
    Abe T, Kaname Y, Wen X, Tani H, Moriishi K, Uematsu S, Takeuchi O, Ishii KJ, Kawai T, Akira S, Matsuura Y.
    Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner.
    J Virol 83(15) 7629-40(2009) 19474102
    Kinpara S, Hasegawa A, Utsunomiya A, Nishitsuji H, Furukawa H, Masuda T, Kannagi M.
    Stromal cell-mediated suppression of human T-cell leukemia virus type 1 expression in vitro and in vivo by type I interferon.
    J Virol 83(10) 5101-8(2009) 19264779
    Yasuda K, Richez C, Maciaszek JW, Agrawal N, Akira S, Marshak-Rothstein A, Rifkin IR.
    Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production.
    J Immunol 178(11) 6876-85(2007) 17513736