Strain Data Sheet

RBRC01421

Strain Information

Image
BRC No.RBRC01421
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6D2-Tg(BGLAP-PTN)1Thg/ThgRbrc
Former Common nameBonerich mouse, BXD-Tg(Hpoc-OSF1)
H-2 Haplotype
ES Cell line
Background strainJcl:B6D2F1
Appearance
Strain development
Strain description
Colony maintenance
References
Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1.
Masuda H, Tsujimura A, Yoshioka M, Arai Y, Kuboki Y, Mukai T, Nakamura T, Tsuji H, Nakagawa M, Hashimoto-Gotoh T
Biochem. Biophys. Res. Commun., 238, 528-533 (1997). 9299545

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
PTN
MGI:97804		PleiotrophinUNPTN transgene insertion 1, Tamotsu Hashimoto-Gotohhuman BGLAP promoter

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal neurocranium morphology(MP:0000074)

  • abnormal skeleton development(MP:0002113)

  • increased bone mineral content(MP:0010123)

  • short femur(MP:0003109)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman BGLAP promoter, human Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) OSF1(=PTN)
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Biochem. Biophy. res. Commun., 238, 528-533 (1997).
    DepositorTamotsu Hashimoto-Gotoh (Kyoto Prefectural University of Medicine)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data