Strain Data Sheet

RBRC01446

update : 2025-02-20

Strain Information
Image
BRC No.	RBRC01446
Type	Spontaneous Mutation
Species	Mus musculus
Strain name	DDY-Dao1<+>/ConnRbrc
Former Common name	ddY/DAO<+> mice
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development	Derived from ddY closed colony.
Strain description	Dao1<c> (Dao1<G181R>) allele arose in some of the ddY closed colony strain. The mice with this allele lack the D-amino acid oxidase activity. This strain is useful for study of D-amino acids.
Colony maintenance	Sibling Mating
References	Mouse mutant deficient in D-amino acid oxidase activity. Konno R, Yasumura Y Genetics, 103, 277-285 (1983). 6131852 Involvement of D-amino-acid oxidase in D-amino acid utilization in the mouse. Konno R, Yasumura Y J. Nutr., 114, 1617-1621 (1984). 6147398 Lack of D-amino-acid oxidase activity causes a specific renal aminoaciduria in the mouse. Konno R, Isobe K, Niwa A, Yasumura Y Biochim. Biophys. Acta., 967, 382-390 (1988). 2904279 Excessive urinary excretion of methionine in mutant mice lacking D-amino-acid oxidase activity. Konno R, Isobe K, Niwa A, Yasumura Y Metabolism, 37, 1139-1142 (1988). 2904113 A simple and rapid method to screen for mutant mice lacking D-amino-acid oxidase activity. Konno R, Yasumura Y Lab. Anim. Sci., 38, 292-295 (1988). 2900911 Presence of D-amino-acid oxidase protein in mutant mice lacking D-amino-acid oxidase activity. Konno R, Yamamoto K, Niwa A, Yasumura Y Int. J. Biochem., 23, 1301-1305 (1991). 1686595 A single-base-pair substitution abolishes D-amino-acid oxidase activity in the mouse. Sasaki M, Konno R, Nishio M, Niwa A, Yasumura Y, Enami J Biochim. Biophys. Acta., 1139, 315-318 (1992). 1355365 Origin of D-alanine present in urine of mutant mice lacking D-amino-acid oxidase activity. Konno R, Oowada T, Ozaki A, Iida T, Niwa A, Yasumura Y, Mizutani T Am. J. Physiol., 265, G699-G703 (1993). 7901999 MouseD-amino-acid oxidase gene: Restriction fragment length polymorphism among mouse strains. Konno R, Sasaki M, Shinohara M, Enami J, Niwa A Amino Acids, 10, 133-143 (1996). 24178475 D-amino-acid oxidase is not present in the mouse liver. Konno R, Sasaki M, Asakura S, Fukui K, Enami J, Niwa A Biochim. Biophys. Acta., 1335, 173-181 (1997). 9133654 more 7 references Nephrotoxicity of D-proparglyglycine in mice. Konno R, Ikeda M, Yamaguchi K, Ueda Y, Niwa A Arch Toxicol., 74, 473-479 (2000). 11097385 Exaggerated responses to chronic nociceptive stimuli and enhancement of N-methyl-D-aspartate receptor-mediated synaptic transmission in mutant mice lacking D-amino-acid oxidase. Wake K, Yamazaki H, Hanzawa S, Konno R, Sakio H, Niwa A, Hori Y Neurosci. Lett., 297, 25-28 (2001). 11114476 Determination of free D-proline and D-leucine in the brains of mutant mice lacking D-amino acid oxidase activity. Hamase K, Inoue T, Morikawa A, Konno R, Zaitsu K Anal. Biochem., 298, 253-258 (2001). 11700980 Determination of free D-aspartic acid, D-serine and D-alanine in the brain of mutant mice lacking D-amino acid oxidase activity. Morikawa A, Hamase K, Inoue T, Konno R, Niwa A, Zaitsu K J. Chromatogr. B, 757, 119-125 (2001). 11419736 Effects of endogenous agonists, glycine and D-serine, on in vivo specific binding of [11C]L-703,717, a PET radioligand for the glycine-binding site of NMDA receptors. Haradahira T, Okauchi T, Maeda J, Zhang M R, Nishikawa T, Konno R, Suzuki K, Suhara T Synapse, 50, 130-136 (2003). 12923815 Role of renal D-amino-acid oxidase in pharmacokinetics of D-leucine. Hasegawa H, Matsukawa T, Shinohara Y, Konno R, Hashimoto T Am. J. Physiol. Endocrinol. Metab., 287, E160-E165 (2004). 15026304 Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801. Hashimoto A, Yoshikawa M, Niwa A, Konno R Brain Res., 1033, 210-215 (2005). 15694926

Health Report
Examination Date / Room / Rack

Gene
Gene Symbol	Gene Name	Chr.	Allele Symbol	Allele Name	Common Names	Promoter	Diseases Related to This Gene
Dao MGI:94859	D-amino acid oxidase	5	Dao

Phenotype
Annotation by Mammalian phenotyhpe ontology	normal phenotype(MP:0002873)
Detailed phenotype data

Ordering Information
Donor DNA
Research application	Cell Biology Research Genetics Research Neurobiology Research Toxicology Research
Specific Term and Conditions	The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC.
Depositor	Ryuichi, Konno (Dokkyo Medical University)
Strain Status	Frozen embryos
Strain Availability	Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month)
Additional Info.	Necessary documents for ordering: Approval form (Japanese / English) Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Genotyping protocol -PCR-

BRC mice in Publications

No Data