Strain Data Sheet

RBRC01462

Strain Information

Image
BRC No.RBRC01462
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Cd38<tm1Okam>/OkamRbrc
Former Common nameC57BL/6-CD38 KO
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenanceHomozygote x Homozygote
References
CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2+]i, and insulin secretion.
Kato I, Yamamoto Y, Fujimura M, Noguchi N, Takasawa S, Okamoto H
J. Biol. Chem., 274, 1869-1872 (1999). 9890936

Health Report

Examination Date / Room / Rack2024/11/25Room:4-CRack:KSentinel mouse program
2024/08/26Room:4-CRack:KSentinel mouse program
2024/05/27Room:4-CRack:KSentinel mouse program
2024/02/26Room:4-CRack:KSentinel mouse program
2023/11/27Room:4-CRack:KSentinel mouse program
2023/08/28Room:4-CRack:KSentinel mouse program
2023/05/29Room:4-CRack:KSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cd38
MGI:107474		CD38 antigen5Cd38<tm1Okam>
MGI:2680868		targeted mutation 1, Hiroshi Okamoto
loxP phage P1 loxP5loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal response/metabolism to endogenous compounds(MP:0003638)

  • decreased circulating insulin level(MP:0002727)

  • decreased insulin secretion(MP:0003059)

  • impaired glucose tolerance(MP:0005293)

  • insulin resistance(MP:0005331)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP site, mouse Cd38 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 274, 1869-1872 (1999). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Users Must obtain permission from Professor Hiroshi OKAMOTO, Tohoku University e-mail: okamotoh@med.tohoku.ac.jp
    DepositorKiyoshi Takatsu (The University of Tokyo)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved embryos (within 1 month)
    Live mouse (1 to 3 months)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data