Strain Data Sheet

RBRC01465

Strain Information

Image
BRC No.RBRC01465
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6(Cg)-Cacna1g<tm1.3Ksak>/KsakRbrc
Former Common nameCa1G KO, C57BL/6-Cacna1g<-/+>
H-2 Haplotype
ES Cell lineBruce 4 [B6.Cg-Thy1<a>]
Background strain
Appearance
Strain development
Strain descriptionCacna1g gene is a member of the low-voltage-activated calcium channel that plays a critcal role in calcium ion transport in nerve, muscle and endocrine cells. This conditional Cacna1g deficient mice were generated by crossing with telencephalin specific Cre transgenic mice.
Colony maintenance
References
Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule.
Nakamura K, Manabe T, Watanabe M, Mamiya T, Ichikawa R, Kiyama Y, Sanbo M, Yagi T, Inoue Y, Nabeshima T, Mori H, Mishina M
Eur. J. Neurosci., 13, 179-189 (2001). 11135016

Conditional activation of RhoA suppresses the epithelial to mesenchymal transition at the primitive streak during mouse gastrulation.
Fuse T, Kanai Y, Kanai-Azuma M, Suzuki M, Nakamura K, Mori H, Hayashi Y, Mishina M
Biochem. Biophys. Res. Commun., 318, 665-672 (2004). 15144889

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cacna1g
MGI:1201678		calcium channel, voltage-dependent, T type, alpha 1G subunit11Cacna1g<tm1.3Ksak> targeted mutation 1.3, Kenji Skimura
  • spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits(MedGEN)

  • spinocerebellar ataxia type 42(MedGEN)
    • loxP phage P1 loxP11loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal single cell response(MP:0003463)

  • impaired behavioral response to xenobiotic(MP:0009747)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP site, mouse Cacna1g genomic DNA
    Research applicationCre/loxP system
    Specific Term and Conditions・The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
    ・The DEPOSITOR should be a co-author in articles when the users publish their data using these mice for 2 year after provided to the RIKEN BRC.
    ・Users should contact the DEPOSITOR in the case of application for any patents with the results from these mice.
    DepositorKenji Sakimura (Niigata University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM.
    CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons.
    Neuropharmacology 135 343-354(2018) 29578032
    Matsumoto-Makidono Y, Nakayama H, Yamasaki M, Miyazaki T, Kobayashi K, Watanabe M, Kano M, Sakimura K, Hashimoto K.
    Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive.
    Cell Rep 16(4) 994-1004(2016) 27425615
    Choi S, Yu E, Hwang E, Llinás RR.
    Pathophysiological implication of CaV3.1 T-type Ca2+ channels in trigeminal neuropathic pain.
    Proc Natl Acad Sci U S A 113(8) 2270-5(2016) 26858455
    Choi S, Yu E, Lee S, Llinás RR.
    Altered thalamocortical rhythmicity and connectivity in mice lacking CaV3.1 T-type Ca2+ channels in unconsciousness.
    Proc Natl Acad Sci U S A 112(25) 7839-44(2015) 26056284
    Handforth A, Homanics GE, Covey DF, Krishnan K, Lee JY, Sakimura K, Martin FC, Quesada A.
    T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor.
    Neuropharmacology 59(6) 380-7(2010) 20547167