Strain Data Sheet

RBRC01489

Strain Information

Image
BRC No.RBRC01489
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Ptprt<tm1Sata>/SataRbrc
Former Common namePTP rho KO 231
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Dr. Masanobu Satake, Tohoku University. C57BL/6 background.
Strain descriptionPTP rho, Protein tyrosine phospatase receptor type T, is a member of the receptor tyrosine phosphatase family. PTPs are signaling molecules that regulate a variety of cellular processes including mitotic cycle, cell growth, differentiation, and oncogenic transformation. At present, homozygous mutant mice show no abnormality.
Colony maintenancebackcross to C57BL/6 (Heterozygote x C57BL/6J)
References
Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.
Zhao Y, Zhang X, Guda K, Lawrence E, Sun Q, Watanabe T, Iwakura Y, Asano M, Wei L, Yang Z, Zheng W, Dawson D, Willis J, Markowitz S D, Satake M, Wang Z
Proc. Natl. Acad. Sci. USA, 107(6):2592-7 (2010). 20133777

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ptprt
MGI:1321152		protein tyrosine phosphatase receptor type T2Ptprt<tm1Sata>
MGI:4437410		targeted mutation 1, Masanobu satake
neo neomycin resistance gene (E. coli)2 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • increased colon adenoma incidence(MP:0002044)

  • increased incidence of tumors by chemical induction(MP:0004499)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, pA, mouse PTP rho genomic DNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
    In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to include the DEPOSITOR as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC.
    The RECIPIENT should contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
    DepositorMasanobu Satake (Tohoku University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Feng X, Scott A, Wang Y, Wang L, Zhao Y, Doerner S, Satake M, Croniger CM, Wang Z.
    PTPRT regulates high-fat diet-induced obesity and insulin resistance.
    PLoS One 9(6) e100783(2014) 24949727