Strain Data Sheet

RBRC01727

Strain Information

Image
BRC No.RBRC01727
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6D2;129-Mafa<tm2Staka>/StakaRbrc
Former Common nameMafA KO clone 2
H-2 Haplotype
ES Cell line
Background strainJcl:B6D2F1
Appearance
Strain development
Strain description
Colony maintenance
References
MafA is a key regulator of glucose-stimulated insulin secretion.
Zhang C, Moriguchi T, Kajihara M, Esaki R, Harada A, Shimohata H, Oishi H, Hamada M, Morito N, Hasegawa K, Kudo T, Engel J D, Yamamoto M, Takahashi S
Mol. Cell. Biol., 25, 4969-4976 (2005). 15923615

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
MafA
MGI:2673307		MAF bZIP transcription factor A15MafA<tm2Staka> targeted mutation 1, Satoru Takahashi
  • islet cell adenomatosis(MedGEN)
    • lacZ beta-galactosidase (E. coli)15
    neo neomycin resistance gene (E. coli)15 herpes simplex virus thymidine kinase promoter (HSV tk promoter)
    nls SV40 large T antigen nuclear localization signal (NLS)15nls

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal pancreatic islet morphology(MP:0005215)

  • decreased circulating insulin level(MP:0002727)

  • decreased insulin secretion(MP:0003059)

  • impaired glucose tolerance(MP:0005293)

  • increased circulating glucose level(MP:0005559)
    • more 2 phenotypes
  • increased urine glucose level(MP:0001759)

  • postnatal growth retardation(MP:0001732)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli beta-galactosidase, E. coli neo resistance gene, Simian virus 40 Large T antigen nuclear localization signal (NLS)
    Research applicationDiabetes and Obesity Research
    covid19_progression
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Cell. Biol., 25, 4969-4976 (2005).
    DepositorSatoru Takahashi (University of Tsukuba)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP

    BRC mice in Publications

    No Data